Acupuncture for reduction of symptom burden in multiple myeloma patients undergoing autologous hematopoietic stem cell transplantation: A randomized sham-controlled trial Journal Article


Authors: Deng, G.; Giralt, S.; Chung, D. J.; Landau, H.; Siman, J.; Search, B.; Coleton, M.; Vertosick, E.; Shapiro, N.; Chien, C.; Wang, X. S.; Cassileth, B.; Mao, J. J.
Article Title: Acupuncture for reduction of symptom burden in multiple myeloma patients undergoing autologous hematopoietic stem cell transplantation: A randomized sham-controlled trial
Abstract: Purpose: Hematopoietic stem cell transplantation (HCT) is potentially curative for a number of hematologic malignancies, but is associated with high symptom burden. We conducted a randomized sham-controlled trial (RCT) to evaluate efficacy and safety of acupuncture as an integrative treatment for managing common symptoms during HCT. Methods: Adult patients with multiple myeloma undergoing high-dose melphalan followed by autologous HCT (AHCT) were randomized to receive either true or sham acupuncture once daily for 5 days starting the day after chemotherapy. Patients and clinical evaluators, but not acupuncturists, were blinded to group assignment. Symptom burden, the primary outcome was assessed with the MD Anderson Symptom Inventory (MDASI) at baseline, during transplantation, and at 15 and 30 days post transplantation. Results: Among 60 participants, true acupuncture produced nonsignificant reductions in overall MDASI core symptom scores and symptom interference scores during transplantation (P = .4 and.3, respectively), at 15 days (P = .10 and.3), and at 30 days posttransplantation (P = .2 and.4) relative to sham. However, true acupuncture was significantly more efficacious in reducing nausea, lack of appetite, and drowsiness at 15 days (P = .042,.025, and.010, respectively). Patients receiving sham acupuncture were more likely to increase pain medication use posttransplantation (odds ratio 5.31, P = .017). Conclusions: Acupuncture was well tolerated with few attributable adverse events. True acupuncture may prevent escalation of symptoms including nausea, lack of appetite, and drowsiness experienced by patients undergoing AHCT, and reduce the use of pain medications. These findings need to be confirmed in a future definitive study. Trial registration: NCT01811862. © 2017, Springer-Verlag GmbH Germany.
Keywords: multiple myeloma; hematopoietic stem cell transplantation; complementary therapies; acupuncture; integrative medicine; symptom management
Journal Title: Supportive Care in Cancer
Volume: 26
Issue: 2
ISSN: 0941-4355
Publisher: Springer Verlag  
Date Published: 2018-02-01
Start Page: 657
End Page: 665
Language: English
DOI: 10.1007/s00520-017-3881-7
PROVIDER: scopus
PUBMED: 28920142
DOI/URL:
Notes: Article -- Export Date: 6 February 2018 -- Source: Scopus
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MSK Authors
  1. Barrie R Cassileth
    189 Cassileth
  2. Sergio Andres Giralt
    535 Giralt
  3. Gary E Deng
    52 Deng
  4. Heather Jolie Landau
    187 Landau
  5. David Chung
    83 Chung
  6. Jun J Mao
    61 Mao
  7. Christine Chien
    2 Chien
  8. Jonathan Siman
    1 Siman
  9. Benjamin Glenn Search
    2 Search