CD11c identifies a subset of murine liver natural killer cells that responds to adenoviral hepatitis Journal Article
| Authors: | Burt, B. M.; Plitas, G.; Stableford, J. A.; Nguyen, H. M.; Bamboat, Z. M.; Pillarisetty, V. G.; DeMatteo, R. P. |
| Article Title: | CD11c identifies a subset of murine liver natural killer cells that responds to adenoviral hepatitis |
| Abstract: | The liver contains a unique repertoire of immune cells and a particular abundance of NK cells. We have found that CD11c defines a distinct subset of NK cells (NK1.1+CD3-) in the murine liver whose function was currently unknown. In naïve animals, CD11c+ liver NK cells displayed an activated phenotype and possessed enhanced effector functions when compared with CD11c- liver NK cells. During the innate response to adenovirus infection, CD11c+ NK cells were the more common IFN-γ-producing NK cells in the liver, demonstrated enhanced lytic capability, and gained a modest degree of APC function. The mechanism of IFN-γ production in vivo depended on TLR9 ligation as well as IL-12 and -18. Taken together, our findings demonstrate that CD11c+ NK cells are a unique subset of NK cells in the murine liver that contribute to the defense against adenoviral hepatitis. © Society for Leukocyte Biology. |
| Keywords: | controlled study; hepatitis; nonhuman; comparative study; animal cell; mouse; phenotype; animals; mice; cell function; animal experiment; animal model; animalia; liver; dendritic cells; gamma interferon; murinae; natural killer cell; killer cells, natural; cytokine production; innate immunity; interleukin 12; immunocompetent cell; adenoviridae; toll-like receptor 9; interleukin 18; lysis; adenovirus; toll like receptor 9; antigens, cd11c; hepatic; interleukin-12; glycoprotein p 15095; ifn-γ; adenoviridae infections; hepatitis, viral, animal; interferon type ii; interleukin-18 |
| Journal Title: | Journal of Leukocyte Biology |
| Volume: | 84 |
| Issue: | 4 |
| ISSN: | 0741-5400 |
| Publisher: | Federation of American Societies for Experimental Biology |
| Date Published: | 2008-10-01 |
| Start Page: | 1039 |
| End Page: | 1046 |
| Language: | English |
| DOI: | 10.1189/jlb.0408256 |
| PUBMED: | 18664530 |
| PROVIDER: | scopus |
| PMCID: | PMC2538591 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 17 November 2011" - "CODEN: JLBIE" - "Source: Scopus" |
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11Stableford -
637DeMatteo -
10
Nguyen -
18
Burt -
29
Pillarisetty -
107Plitas -
33
Bamboat
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