Molecular basis for the regenerative properties of a secretion of the mollusk Cryptomphalus aspersa Journal Article


Authors: Brieva, A.; Philips, N.; Tejedor, R.; Guerrero, A.; Pivel, J. P.; Alonso-Lebrero, J. L.; Gonzalez, S.
Article Title: Molecular basis for the regenerative properties of a secretion of the mollusk Cryptomphalus aspersa
Alternate Title: Skin Pharmacology and Physiology
Abstract: A screen for natural products bearing pharmacological properties has yielded a secretion of the mollusk Cryptomphalus aspersa (SCA), which possesses skin-regenerative properties. In this report, we outline some of the cellular and molecular effects underlying this observation. First, we found that SCA contained antioxidant SOD and GST activities. In addition, SCA stimulated fibroblast proliferation and rearrangement of the actin cytoskeleton. Additional mechanisms involved in the regenerative effect of SCA included the stimulation of extracellular matrix assembly and the regulation of metalloproteinase activities. Together, these effects provide an array of molecular mechanisms underlying SCA-induced cellular regeneration and postulate its use in regeneration of wounded tissue. Copyright © 2007 S. Karger AG.
Keywords: controlled study; human tissue; human cell; nonhuman; cell proliferation; animal cell; animals; actin; cells, cultured; down-regulation; enzyme activity; extracellular matrix; wound healing; regeneration; glutathione transferase; fibroblasts; antioxidant; antioxidants; antioxidant activity; cell regeneration; natural product; superoxide dismutase; cytoskeleton; metalloproteinase; matrix metalloproteinase 1; skin fibroblast; skin aging; cho cells; cricetinae; cricetulus; c. aspersa, cellular and molecular effects; cryptomphalus aspersa; extracellular matrix assembly; mollusk; sca, regenerative properties; mollusc; matrix metalloproteinase 2; snails
Journal Title: Skin Pharmacology and Physiology
Volume: 21
Issue: 1
ISSN: 1660-5527
Publisher: Karger  
Date Published: 2008-01-01
Start Page: 15
End Page: 22
Language: English
DOI: 10.1159/000109084
PUBMED: 17912020
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 3" - "Export Date: 17 November 2011" - "CODEN: SPPKC" - "Source: Scopus"