Molecular basis for the regenerative properties of a secretion of the mollusk Cryptomphalus aspersa Journal Article
| Authors: | Brieva, A.; Philips, N.; Tejedor, R.; Guerrero, A.; Pivel, J. P.; Alonso-Lebrero, J. L.; Gonzalez, S. |
| Article Title: | Molecular basis for the regenerative properties of a secretion of the mollusk Cryptomphalus aspersa |
| Abstract: | A screen for natural products bearing pharmacological properties has yielded a secretion of the mollusk Cryptomphalus aspersa (SCA), which possesses skin-regenerative properties. In this report, we outline some of the cellular and molecular effects underlying this observation. First, we found that SCA contained antioxidant SOD and GST activities. In addition, SCA stimulated fibroblast proliferation and rearrangement of the actin cytoskeleton. Additional mechanisms involved in the regenerative effect of SCA included the stimulation of extracellular matrix assembly and the regulation of metalloproteinase activities. Together, these effects provide an array of molecular mechanisms underlying SCA-induced cellular regeneration and postulate its use in regeneration of wounded tissue. Copyright © 2007 S. Karger AG. |
| Keywords: | controlled study; human tissue; human cell; nonhuman; cell proliferation; animal cell; animals; actin; cells, cultured; down-regulation; enzyme activity; extracellular matrix; wound healing; regeneration; glutathione transferase; fibroblasts; antioxidant; antioxidants; antioxidant activity; cell regeneration; natural product; superoxide dismutase; cytoskeleton; metalloproteinase; matrix metalloproteinase 1; skin fibroblast; skin aging; cho cells; cricetinae; cricetulus; c. aspersa, cellular and molecular effects; cryptomphalus aspersa; extracellular matrix assembly; mollusk; sca, regenerative properties; mollusc; matrix metalloproteinase 2; snails |
| Journal Title: | Skin Pharmacology and Physiology |
| Volume: | 21 |
| Issue: | 1 |
| ISSN: | 1660-5527 |
| Publisher: | S. Karger AG |
| Date Published: | 2008-01-01 |
| Start Page: | 15 |
| End Page: | 22 |
| Language: | English |
| DOI: | 10.1159/000109084 |
| PUBMED: | 17912020 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 17 November 2011" - "CODEN: SPPKC" - "Source: Scopus" |
