Preoperative combined modality treatment for rectal cancer Journal Article
| Author: | Minsky, B. D. |
| Article Title: | Preoperative combined modality treatment for rectal cancer |
| Abstract: | The encouraging results achieved with adjuvant postoperative combined modality therapy in patients with resectable rectal cancer has prompted an increased interest in preoperative combined modality therapy. Based on the potential of such regimens to deliver higher chemotherapy doses, enhance downstaging, and decrease acute toxicity in patients with unresectable disease, this approach is attractive in patients with resectable rectal cancer. Randomized trials of preoperative vs postoperative combined modality therapy using combinations of bolus fluorouracil and leucovorin are in progress. |
| Keywords: | cancer chemotherapy; cancer survival; cancer surgery; clinical trial; review; fluorouracil; combined modality therapy; antineoplastic agent; phase 2 clinical trial; bone marrow suppression; gastrointestinal toxicity; cancer regression; randomized controlled trials; folinic acid; phase 1 clinical trial; rectal neoplasms; rectum cancer; leucovorin; human |
| Journal Title: | Oncology (Norwalk) |
| Volume: | 8 |
| Issue: | 5 |
| ISSN: | 0890-9091 |
| Publisher: | C M P Medica LLC * The Oncology Group |
| Date Published: | 1994-05-01 |
| Start Page: | 53 |
| End Page: | 58, 61; discussion 61, 64-68 |
| Language: | English |
| PUBMED: | 8025007 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
