Drug/dye-loaded, multifunctional iron oxide nanoparticles for combined targeted cancer therapy and dual optical/magnetic resonance imaging Journal Article
| Authors: | Santra, S.; Kaittanis, C.; Grimm, J.; Perez, J. M. |
| Article Title: | Drug/dye-loaded, multifunctional iron oxide nanoparticles for combined targeted cancer therapy and dual optical/magnetic resonance imaging |
| Abstract: | A biocompatible, multimodal, and theranostic functional iron oxide nanoparticle is synthesized using a novel water-based method and exerts excellent properties for targeted cancer therapy, and optical and magnetic resonance imaging. For the first time, a facile, modified solvent diffusion method is used for the co-encapsulation of both an anticancer drug and near-infrared dyes. The resulting folate-derivatized theranostics nanoparticles could allow for targeted optical/magnetic resonance imaging andtargeted killing of folate-expressing cancer cells. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA. |
| Keywords: | antineoplastic agents; nuclear magnetic resonance imaging; methodology; magnetic resonance imaging; antineoplastic agent; neoplasm; neoplasms; metabolism; diffusion; fluorescent dye; fluorescent dyes; drug delivery systems; chemistry; ligand; magnetic resonance; ligands; nanoparticles; folic acid; magnetic materials; optics; optics and photonics; drug delivery system; cancer cells; nanotechnology; infrared spectrophotometry; spectrophotometry, infrared; click chemistry; drug delivery; anticancer drug; co-encapsulation; iron oxide nanoparticle; multi-modal; near-infrared dyes; solvent diffusion methods; targeted cancer therapy; theranostics; water-based methods; magnetic devices; magnetism; optical properties; iron oxides; ferric ion; ferric oxide; metal nanoparticle; solvent; ferric compounds; magnetics; metal nanoparticles; solvents |
| Journal Title: | Small |
| Volume: | 5 |
| Issue: | 16 |
| ISSN: | 1613-6810 |
| Publisher: | Wiley V C H Verlag Gmbh |
| Date Published: | 2009-08-17 |
| Start Page: | 1862 |
| End Page: | 1868 |
| Language: | English |
| DOI: | 10.1002/smll.200900389 |
| PUBMED: | 19384879 |
| PROVIDER: | scopus |
| PMCID: | PMC3057065 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 17" - "Export Date: 30 November 2010" - "Source: Scopus" |
