Investigating the cellular specificity in tumors of a surface-converting nanoparticle by multimodal imaging Journal Article
| Authors: | Fay, F.; Hansen, L.; Hectors, S. J. C. G.; Sanchez-Gaytan, B. L.; Zhao, Y.; Tang, J.; Munitz, J.; Alaarg, A.; Braza, M. S.; Gianella, A.; Aaronson, S. A.; Reiner, T.; Kjems, J.; Langer, R.; Hoeben, F. J. M.; Janssen, H. M.; Calcagno, C.; Strijkers, G. J.; Fayad, Z. A.; Pérez-Medina, C.; Mulder, W. J. M. |
| Article Title: | Investigating the cellular specificity in tumors of a surface-converting nanoparticle by multimodal imaging |
| Abstract: | Active targeting of nanoparticles through surface functionalization is a common strategy to enhance tumor delivery specificity. However, active targeting strategies tend to work against long polyethylene glycol's shielding effectiveness and associated favorable pharmacokinetics. To overcome these limitations, we developed a matrix metalloproteinase-2 sensitive surface-converting polyethylene glycol coating. This coating prevents nanoparticle-cell interaction in the bloodstream, but, once exposed to matrix metalloproteinase-2, i.e., when the nanoparticles accumulate within the tumor interstitium, the converting polyethylene glycol coating is cleaved, and targeting ligands become available for binding to tumor cells. In this study, we applied a comprehensive multimodal imaging strategy involving optical, nuclear, and magnetic resonance imaging methods to evaluate this coating approach in a breast tumor mouse model. The data obtained revealed that this surface-converting coating enhances the nanoparticle's blood half-life and tumor accumulation and ultimately results in improved tumor-cell targeting. Our results show that this enzyme-specific surface-converting coating ensures a high cell-targeting specificity without compromising favorable nanoparticle pharmacokinetics. © 2017 American Chemical Society. |
| Journal Title: | Bioconjugate Chemistry |
| Volume: | 28 |
| Issue: | 5 |
| ISSN: | 1043-1802 |
| Publisher: | American Chemical Society |
| Date Published: | 2017-05-17 |
| Start Page: | 1413 |
| End Page: | 1421 |
| Language: | English |
| DOI: | 10.1021/acs.bioconjchem.7b00086 |
| PROVIDER: | scopus |
| PUBMED: | 28316241 |
| PMCID: | PMC5567755 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 July 2017 -- Source: Scopus |
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