Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth Journal Article
| Authors: | Kim, S. E.; Zhang, L.; Ma, K.; Riegman, M.; Chen, F.; Ingold, I.; Conrad, M.; Turker, M. Z.; Gao, M.; Jiang, X.; Monette, S.; Pauliah, M.; Gonen, M.; Zanzonico, P.; Quinn, T.; Wiesner, U.; Bradbury, M. S.; Overholtzer, M. |
| Article Title: | Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth |
| Abstract: | The design of cancer-targeting particles with precisely tuned physicochemical properties may enhance the delivery of therapeutics and access to pharmacological targets. However, a molecular-level understanding of the interactions driving the fate of nanomedicine in biological systems remains elusive. Here, we show that ultrasmall (<10nm in diameter) poly(ethylene glycol)-coated silica nanoparticles, functionalized with melanoma-targeting peptides, can induce a form of programmed cell death known as ferroptosis in starved cancer cells and cancer-bearing mice. Tumour xenografts in mice intravenously injected with nanoparticles using a high-dose multiple injection scheme exhibit reduced growth or regression, in a manner that is reversed by the pharmacological inhibitor of ferroptosis, liproxstatin-1. These data demonstrate that ferroptosis can be targeted by ultrasmall silica nanoparticles and may have therapeutic potential. |
| Journal Title: | Nature Nanotechnology |
| Volume: | 11 |
| Issue: | 11 |
| ISSN: | 1748-3387 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2016-11-01 |
| Start Page: | 977 |
| End Page: | 985 |
| Language: | English |
| DOI: | 10.1038/nnano.2016.164 |
| PROVIDER: | scopus |
| PMCID: | PMC5108575 |
| PUBMED: | 27668796 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 December 2016 -- Source: Scopus |
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