Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer Journal Article


Authors: Chen, F.; Ma, K.; Madajewski, B.; Zhuang, L.; Zhang, L.; Rickert, K.; Marelli, M.; Yoo, B.; Turker, M. Z.; Overholtzer, M.; Quinn, T. P.; Gonen, M.; Zanzonico, P.; Tuesca, A.; Bowen, M. A.; Norton, L.; Subramony, J. A.; Wiesner, U.; Bradbury, M. S.
Article Title: Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer
Abstract: Controlling the biodistribution of nanoparticles upon intravenous injection is the key to achieving target specificity. One of the impediments in nanoparticle-based tumor targeting is the inability to limit the trafficking of nanoparticles to liver and other organs leading to smaller accumulated amounts in tumor tissues, particularly via passive targeting. Here we overcome both these challenges by designing nanoparticles that combine the specificity of antibodies with favorable particle biodistribution profiles, while not exceeding the threshold for renal filtration as a combined vehicle. To that end, ultrasmall silica nanoparticles are functionalized with anti-human epidermal growth factor receptor 2 (HER2) single-chain variable fragments to exhibit high tumor-targeting efficiency and efficient renal clearance. This ultrasmall targeted nanotheranostics/nanotherapeutic platform has broad utility, both for imaging a variety of tumor tissues by suitably adopting the targeting fragment and as a potentially useful drug delivery vehicle. © 2018, The Author(s).
Keywords: silica; nanoparticle; tumor; antibody; threshold; bioengineering; detection method; filtration; cancer
Journal Title: Nature Communications
Volume: 9
ISSN: 2041-1723
Publisher: Nature Publishing Group  
Date Published: 2018-10-08
Start Page: 4141
Language: English
DOI: 10.1038/s41467-018-06271-5
PUBMED: 30297810
PROVIDER: scopus
PMCID: PMC6175906
DOI/URL:
Notes: Article -- Export Date: 1 November 2018 -- Source: Scopus
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MSK Authors
  1. Larry Norton
    557 Norton
  2. Mithat Gonen
    701 Gonen
  3. Pat B Zanzonico
    246 Zanzonico
  4. Barney Yoo
    9 Yoo
  5. Li Zhang
    8 Zhang
  6. Feng   Chen
    7 Chen