NK cell imaging by in vitro and in vivo labelling approaches Journal Article
| Authors: | Galli, F.; Histed, S.; Aras, O. |
| Article Title: | NK cell imaging by in vitro and in vivo labelling approaches |
| Abstract: | Natural killer (NK) cells are a particular lymphocyte subset with a documented cytotoxic activity against cancer cells. Evidence of NK antitumoral effect led researchers to focus on the development of immunotherapies aimed at augmenting NK recruitment and infiltration into tumor and their anti-cancer functions. Studies in animal models proved that the right combination of drugs, cytokines, chemokines and other factors might be used to enhance or suppress tumor targeting by NK cells. Therefore, it would be necessary to have a tool to non-invasively monitor the efficacy of such novel therapies. Available imaging techniques comprise magnetic resonance, optical and nuclear medicine imaging with a pool of compounds that ranges from radiolabelled nanoparticles and radiopharmaceuticals to fluorescent probes. Each tracer and technique has its own pros and cons, but till now, no one emerged as superior among the others. |
| Keywords: | radiopharmaceuticals; neoplasm; neoplasms; t lymphocyte; t-lymphocytes; animal; animals; pathology; immunology; isotope labeling; computer assisted emission tomography; radiopharmaceutical agent; scintiscanning; natural killer cell; killer cells, natural; cell tracking; tomography, emission-computed; procedures; humans; human; diagnostic use |
| Journal Title: | Quarterly Journal of Nuclear Medicine and Molecular Imaging |
| Volume: | 58 |
| Issue: | 3 |
| ISSN: | 1824-4785 |
| Publisher: | Edizioni Minerva Medica |
| Date Published: | 2014-09-01 |
| Start Page: | 276 |
| End Page: | 283 |
| Language: | English |
| PUBMED: | 25265248 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 2 April 2015 -- The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutical Chemistry and Biology -- Source: Scopus |
