Synthesis and antiviral activity of some fluorinated nucleotide derivatives Journal Article

  


Authors: Dyatkina, N.; Arzumanov, A.; Krayevsky, A.; O'Hara, B.; Gluzman, Y.; Baron, P.; Maclow, C.; Polsky, B.
Article Title: Synthesis and antiviral activity of some fluorinated nucleotide derivatives
Abstract: A number of 3’-fluoro-3’-deoxythyinidine 5’-phosphonates and nucleoside 5’-phosphorofluoridates were prepared to study their ability to inhibit replication of HIV-1. Compounds, the 5’-phosphorofluoridates of 3'-azido-3’-deoxythymidine (VIIIc). 3’fluoro-3’-deoxythyinidine (VIIId) and 3'-deoxy-2,,3’-didehydrothymidine (VIIIe), exhibit potent anti-HIV-1 activities. © 1994, Taylor & Francis Group, LLC. All rights reserved.
Keywords: unclassified drug; nonhuman; drug potency; drug structure; drug synthesis; antivirus agent; proton nuclear magnetic resonance; antiviral activity; human immunodeficiency virus 1; virus inhibition; fluorination; article; 3' fluoro 3' deoxythymidine 5' phosphonic acid derivative; 3' fluorothymidine derivative; stavudine derivative; zidovudine derivative
Journal Title: Nucleosides & Nucleotides
Volume: 13
Issue: 1-3
ISSN: 0732-8311
Publisher: Taylor & Francis Inc.  
Date Published: 1994-01-01
Start Page: 325
End Page: 337
Language: English
DOI: 10.1080/15257779408013244
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028354166&doi=10.1080%2f15257779408013244&partnerID=40&md5=3d9257c4af45cd0fd61cfda0e3093db4
Notes: Export Date: 14 January 2019 -- Article -- Source: Scopus
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MSK Authors
  1. Bruce Polsky
    69 Polsky
  2. Penny A Baron
    27 Baron
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