T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice Journal Article
| Authors: | Dudley, E. C.; Petrie, H. T.; Shah, L. M.; Owen, M. J.; Hayday, A. C. |
| Article Title: | T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice |
| Abstract: | The identification is made in normal mice of the stages in T cell development at which the rearranged β chain of the T cell receptor (TCR) is utilized to promote T cell maturation, independent of the TCRu chain. In addition, evidence is provided that utilization of β chains in T cell progenitors does not preclude differentiation to TCRγδ+ T cells. This is consistent with the view that an initial consequence of β chain expression by early thymocytes is clonal expansion, increasing the size of the pool of useful precursors. This allows the proposal to be made that allelic exclusion may be a byproduct of cell cycle regulation during early thymocyte differentiation, which may in turn explain why the efficiency of allelic exclusion varies at different TCR or immunoglobulin loci. © 1994. |
| Keywords: | carrier protein; genetics; molecular genetics; polymerase chain reaction; t lymphocyte; t-lymphocytes; mouse; animal; cytology; metabolism; mice; biological model; models, biological; cell differentiation; mice, inbred c57bl; immunology; dna; gene rearrangement; molecular sequence data; nucleotide sequence; carrier proteins; base sequence; t-lymphocyte subsets; dna primers; primer dna; mouse strain; hermes antigen; t lymphocyte subpopulation; lymphocyte antigen receptor; cell surface receptor; receptors, cell surface; receptors, antigen, t-cell, gamma-delta; interleukin 2 receptor; receptors, interleukin-2; restriction fragment length polymorphism; polymorphism, restriction fragment length; antigens, cd44; homing receptor; receptors, lymphocyte homing; article; gene rearrangement, beta-chain t-cell antigen receptor; receptors, antigen, t cell, gamma delta; receptors, interleukin 2 |
| Journal Title: | Immunity |
| Volume: | 1 |
| Issue: | 2 |
| ISSN: | 1074-7613 |
| Publisher: | Cell Press |
| Date Published: | 1994-05-01 |
| Start Page: | 83 |
| End Page: | 93 |
| Language: | English |
| DOI: | 10.1016/1074-7613(94)90102-3 |
| PROVIDER: | scopus |
| PUBMED: | 7534200 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- Source: Scopus |
