Antibody response to murine anti-G(D2) monoclonal antibodies: Correlation with patient survival Journal Article


Authors: Cheung, N. K. V.; Cheung, I. Y.; Canete, A.; Yeh, S. J.; Kushner, B.; Bonilla, M. A.; Heller, G.; Larson, S. M.
Article Title: Antibody response to murine anti-G(D2) monoclonal antibodies: Correlation with patient survival
Abstract: Clinical strategies which modulate the human anti-mouse antibody response (HAMA) in patients may have a profound influence on the idiotype network inducible by murine monoclonal antibodies (MoAb). Prior to myeloablative chemotherapy (ABMT), 9 patients with Stage IV neuroblastoma were imaged with 131I-3F8, a MoAb specific for the ganglioside GD2. Their serum HAMA, anti-idiotypic, anti-GD2, and anti-anti-idiotypic antibodies were assayed by enzyme-linked immunosorbent assay prior to, and at 3 and 6 months postimaging. HAMA and anti-idiotypic levels remained low, in contrast to the high levels in 10 patients imaged with 131I-3F8 Iro without ABMT. Five of the 9 patients are long-term survivors; all had elevated anti-GD2 and anti-anti-idiotypic levels, significantly higher than those who died of disease. Although 131I-3F8 imaging prior to ABMT detected abnormal sites in 4 of 9 patients, 3 of the 4 patients have continued in remission for 24–63 months after ABMT, and all 3 mounted anti-GD2 and anti-anti-idiotypic antibody responses. We conclude that myeloablative therapy strongly suppressed the HAMA/anti-idiotypic response to murine MoAb and that the prognostic significance of host immune response to ganglioside GD2 MoAb deserves further investigation. © 1994, American Association for Cancer Research. All rights reserved.
Keywords: cancer survival; clinical article; controlled study; survival analysis; survival rate; cisplatin; neoplasm staging; animal; mice; bone marrow suppression; etoposide; antineoplastic combined chemotherapy protocols; radiotherapy dosage; melphalan; carmustine; thiotepa; monoclonal antibody; antibodies, monoclonal; neuroblastoma; antibody response; immunoassay; enzyme-linked immunosorbent assay; bone marrow transplantation; antibody formation; gangliosides; ganglioside antibody; antibodies, anti-idiotypic; antibody blood level; prognosis; human; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.
Journal Title: Cancer Research
Volume: 54
Issue: 8
ISSN: 0008-5472
Publisher: American Association for Cancer Research  
Date Published: 1994-04-15
Start Page: 2228
End Page: 2233
Language: English
PROVIDER: scopus
PUBMED: 8174131
DOI/URL:
Notes: Export Date: 14 January 2019 -- Article -- Source: Scopus
Citation Impact
MSK Authors
  1. Samuel D J Yeh
    102 Yeh
  2. Brian Kushner
    270 Kushner
  3. Glenn Heller
    372 Heller
  4. Nai-Kong Cheung
    579 Cheung
  5. Irene Y Cheung
    85 Cheung
  6. Steven M Larson
    910 Larson
  7. Mary Ann Bonilla
    31 Bonilla