Correlation of anti-idiotype network with survival following anti-G(D2) monoclonal antibody 3F8 therapy of stage 4 neuroblastoma Journal Article
| Authors: | Cheung, N. K. V.; Guo, H. F. ; Cheung, I. Y. |
| Article Title: | Correlation of anti-idiotype network with survival following anti-G(D2) monoclonal antibody 3F8 therapy of stage 4 neuroblastoma |
| Abstract: | Background. A transient human anti-mouse antibody response was associated with significantly longer survival [Cheung et al. (1998): J Clin Oncol 16:3053] following antibody 3F8 (Ab1) treatment. We postulate that the induction of an idiotype network which included anti-anti-idiotypic (Ab3) and anti-G(D2) (Ab3') responses is associated with tumor control. Procedure. Thirty-four patients with stage 4 neuroblastoma (NB) diagnosed at > 1 year of age were treated with anti-G(D2) monoclonal antibody 3F8 at the end of chemotherapy. Results. Long-term progression-free survival and overall survival correlated significantly with Ab3' andAb3, but not with non-idiotypic antibody responses. Only one of six individual specificities showed significant correlations with patient survival. Conclusions. As in vitro correlates of idiotype network initiated by Ab1 treatment, Ab3 and Ab3' may provide convenient biologic endpoints for monoclonal antibody therapy of advanced NB, and a rationale for choosing specific anti-idiotypic antibodies for vaccine development. (C) 2000 Wiley-Liss, Inc. |
| Keywords: | cancer survival; survival rate; human cell; antineoplastic agents; conference paper; neoplasm staging; cell survival; monoclonal antibody; antibodies, monoclonal; immunotherapy; neuroblastoma; antibody response; binding site; cancer control; vaccine production; antigen binding; antibody dependent cellular cytotoxicity; complement dependent cytotoxicity; antibodies, anti-idiotypic; protein-tyrosine-phosphatase; antigenicity; antiidiotypic antibody; proteochondroitin sulfates; humans; human; priority journal; hama; long-term tumor control |
| Journal Title: | Medical and Pediatric Oncology |
| Volume: | 35 |
| Issue: | 6 |
| ISSN: | 0098-1532 |
| Publisher: | Wiley Liss |
| Date Published: | 2000-12-01 |
| Start Page: | 635 |
| End Page: | 637 |
| Language: | English |
| DOI: | 10.1002/1096-911x(20001201)35:6<635::aid-mpo32>3.0.co;2-w |
| PUBMED: | 11107135 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
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