Acute pain relief after mantram meditation in children with neuroblastoma undergoing anti-GD2 monoclonal antibody therapy Journal Article


Authors: Ahmed, M.; Modak, S.; Sequeira, S.
Article Title: Acute pain relief after mantram meditation in children with neuroblastoma undergoing anti-GD2 monoclonal antibody therapy
Abstract: Nonpharmacologic, mind-body interventions are used to reduce anxiety in pediatric patients. Anti-ganglioside GD2 monoclonal antibody (anti-GD2 MoAb 3F8) therapy is the standard of care for high-risk neuroblastoma and pain is its major side effect. We performed a retrospective analysis of children undergoing anti-GD2 MoAb 3F8 treatment who received guided meditation. Meditation involved concentrating on the repetition of rhythmic, melodic sounds purported to slow breathing and induce a relaxation response. A total of 71% patients completed a session at first (n=19) or second attempt (n=5). Patients received fewer analgesic doses to manage anti-GD2 MoAb 3F8-induced pain when participating in meditation (n=17, mean=-0.4 dose, P<0.01). Mantram meditation is a feasible outpatient intervention associated with reduced analgesic requirements. Copyright © 2013 by Lippincott Williams & Wilkins.
Keywords: adolescent; child; clinical article; controlled study; child, preschool; retrospective studies; unclassified drug; antineoplastic agents; cancer immunotherapy; pain; granulocyte macrophage colony stimulating factor; retrospective study; monoclonal antibody; antibodies, monoclonal; feasibility study; neuroblastoma; clinical effectiveness; meditation; children; hydromorphone; analgesia; pain assessment; monoclonal antibody 3f8; gangliosides; heart rate; humans; human; male; female; priority journal; article; mantram; mantram meditation
Journal Title: Journal of Pediatric Hematology/Oncology
Volume: 36
Issue: 2
ISSN: 1077-4114
Publisher: Lippincott Williams & Wilkins  
Date Published: 2014-03-01
Start Page: 152
End Page: 155
Language: English
DOI: 10.1097/mph.0000000000000024
PROVIDER: scopus
PUBMED: 24065045
DOI/URL:
Notes: Cited By (since 1996):1 -- Export Date: 2 April 2014 -- CODEN: JPHOF -- Source: Scopus
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MSK Authors
  1. Shakeel Modak
    201 Modak
  2. Mahiuddin Ahmed
    14 Ahmed