Biological study of r24 mouse monoclonal antibody in patients undergoing thoracotomy for pulmonary metastases from soft tissue sarcoma Journal Article
| Authors: | Casper, E. S.; Cordon-Cardo, C.; Houghton, A. N.; Steffens, T. A.; McCormack, P.; Magill, G. B.; Hajdu, S. I.; Brennan, M. F. |
| Article Title: | Biological study of r24 mouse monoclonal antibody in patients undergoing thoracotomy for pulmonary metastases from soft tissue sarcoma |
| Abstract: | The disialoganglioside GD3 is expressed on the surface of soft tissue sarcoma, malignant melanoma, and other malignant cells and is, therefore, a potential target for therapeutic monoclonal antibodies. Intravenously administered R24, a murine IgG3 monoclonal antibody to GD3, induces inflammation and tumor regression at sites of metastatic malignant melanoma. R24 5 mg/m2 was given intravenously every other day for six doses to 10 patients with pulmonary metastases from a primary soft tissue sarcoma of the extremity for whom thoracotomy was planned. Resected tissue was available from 7 patients. All metastases expressed GD3; however, expression was heterogeneous within tumors, and in no tumor were more than 80% of the cells GD3 positive. A mild to moderate infiltrate consisting of mononuclear cells with T-cell markers was identified around or within pulmonary metastases in 6 patients. Tolerable acute allergic reactions occurred in all patients, but 3 patients had severe chest tightness and bronchospasm that limited the planned therapy. The setting of thoracotomy for metastatic disease provides an ideal system for studies on the pharmacology and biological effects of monoclonal antibodies that target soft tissue sarcoma antigens. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |
| Keywords: | osteosarcoma; adult; clinical article; human tissue; aged; clinical trial; chemotherapy, adjuvant; animal; mice; cancer immunotherapy; allergy; lung neoplasms; monoclonal antibody; sarcoma; lung metastasis; antibodies, monoclonal; thigh; nonsteroid antiinflammatory agent; soft tissue sarcoma; glucocorticoid; infusions, intravenous; ganglioside gd3; soft tissue neoplasms; liposarcoma; intravenous drug administration; leg; diphenhydramine; intradermal drug administration; gangliosides; middle age; adrenalin; hybridomas; epinephrine; human; male; female; priority journal; article; monoclonal antibody r24; support, u.s. gov't, p.h.s.; histiocytoma, fibrous; intradermal tests |
| Journal Title: | Cancer Investigation |
| Volume: | 12 |
| Issue: | 1 |
| ISSN: | 0735-7907 |
| Publisher: | Informa Healthcare |
| Date Published: | 1994-01-01 |
| Start Page: | 20 |
| End Page: | 25 |
| Language: | English |
| DOI: | 10.3109/07357909409021389 |
| PROVIDER: | scopus |
| PUBMED: | 8281462 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- Source: Scopus |
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