Abstract: |
Almost 70 years ago, George Hevesy initiated the use of radioactive tracers to map metabolic processes (1,2). In the mid-1930s, studies in human subjects were accomplished primarily in the thyroid gland using radioactive iodine (I-131). For many decades, I-131 remained the only specific radionuclide for the diagnosis and treatment of thyroid diseases (3-7). Subsequently, phosphorus (P-32) was used for treatment of patients with bone tumors, leukemia, polycythemia vera, and bony metastases from cancer of the breast and prostate. Prior to the development of computed tomography (CT) scanning and magnetic resonance imaging (MRI), abdominal ultrasound, plain radiographs, and pyelography were the means of initial evaluation of the adrenal masses. Definitive diagnosis was made by invasive procedures like arteriography, venography, and adrenal venous sampling. © 2003 by Taylor and Francis Group, LLC. |