The evolving role of 131I for the treatment of differentiated thyroid carcinoma Journal Article
| Authors: | Robbins, R. J.; Schlumberger, M. J. |
| Article Title: | The evolving role of 131I for the treatment of differentiated thyroid carcinoma |
| Abstract: | The use of radioactive iodine (131I) for the treatment of thyroid carcinoma has changed over the past 50 y. These changes are based on increasing awareness of the biophysical properties of 131I and new discoveries concerning the biology of iodine handling by thyroid cells. The therapeutic administration of 131I for thyroid remnant ablation and for metastases requires an appreciation of iodine clearance kinetics, of factors that can alter the occupancy time of 131I within lesions, and of the role of thyroid-stimulating hormone in stimulating the sodium-iodide symporter. The potential complications and adverse events associated with 131I are discussed. 131I will continue to be a major weapon in the fight against metastatic thyroid carcinoma. Its future role will be modified by expanding knowledge of its relative risks and benefits. |
| Keywords: | treatment outcome; cancer surgery; clinical trial; mortality; review; cancer localization; cancer recurrence; drug withdrawal; adjuvant therapy; radiotherapy, adjuvant; positron emission tomography; methodology; radiopharmaceuticals; clinical practice; physician's practice patterns; animal; animals; heredity; edema; metastasis; infection; neoplasm recurrence, local; nausea; practice guideline; gonadal disease; carcinogenesis; iodine 131; radioactive iodine; iodine radioisotopes; dosimetry; tumor recurrence; fluorodeoxyglucose f 18; carcinoma; radiopharmaceutical agent; xerostomia; ionizing radiation; drug clearance; salivary gland disease; thyroid carcinoma; thyroid neoplasms; drug metabolism; external beam radiotherapy; eye disease; drug half life; metastases; corticosteroid; radiation safety; drug contraindication; radiation dose distribution; thyroid tumor; clinical trials; thyrotropin; female infertility; electron; adverse effects; swelling; lacrimal duct occlusion; sialoadenitis; sodium iodide symporter; practice guidelines; stomach pain |
| Journal Title: | Journal of Nuclear Medicine |
| Volume: | 46 |
| Issue: | 1 Suppl. |
| ISSN: | 0161-5505 |
| Publisher: | Society of Nuclear Medicine |
| Date Published: | 2005-01-01 |
| Start Page: | 28S |
| End Page: | 37S |
| Language: | English |
| PUBMED: | 15653649 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 73" - "Export Date: 24 October 2012" - "CODEN: JNMEA" - "Source: Scopus" |
