NK cell development, homeostasis and function: Parallels with CD8 + T cells Journal Article
| Authors: | Sun, J. C.; Lanier, L. L. |
| Article Title: | NK cell development, homeostasis and function: Parallels with CD8 + T cells |
| Abstract: | Natural killer (NK) cells survey host tissues for signs of infection, transformation or stress and, true to their name, kill target cells that have become useless or are detrimental to the host. For decades, NK cells have been classified as a component of the innate immune system. However, accumulating evidence in mice and humans suggests that, like the B and T cells of the adaptive immune system, NK cells are educated during development, possess antigen-specific receptors, undergo clonal expansion during infection and generate long-lived memory cells. In this Review, we highlight the many stages that an NK cell progresses through during its remarkable lifetime, discussing similarities and differences with its close relative, the cytotoxic CD8 + T cell. © 2011 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | unclassified drug; review; nonhuman; cd8+ t lymphocyte; cell proliferation; cell survival; cell function; cell maturation; cell differentiation; cell lineage; lymphocytopenia; cellular immunity; antigen specificity; cell migration; cellular distribution; natural killer cell; virus infection; memory cell; homeostasis; basic leucine zipper transcription factor; t lymphocyte activation; interleukin 15; basic leucine zipper transcription factor e4bp4 |
| Journal Title: | Nature Reviews Immunology |
| Volume: | 11 |
| Issue: | 10 |
| ISSN: | 1474-1733 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2011-08-26 |
| Start Page: | 645 |
| End Page: | 657 |
| Language: | English |
| DOI: | 10.1038/nri3044 |
| PROVIDER: | scopus |
| PUBMED: | 21869816 |
| PMCID: | PMC4408539 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 November 2011" - "CODEN: NRIAB" - "Source: Scopus" |
