Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006 Journal Article


Authors: Park, B. J.; Pappas, P. G.; Wannemuehler, K. A.; Alexander, B. D.; Anaissie, E. J.; Andes, D. R.; Baddley, J. W.; Brown, J. M.; Brumble, L. M.; Freifeld, A. G.; Hadley, S.; Herwaldt, L.; Ito, J. I.; Kauffman, C. A.; Lyon, G. M.; Marr, K. A.; Morrison, V. A.; Papanicolaou, G.; Patterson, T. F.; Perl, T. M.; Schuster, M. G.; Walker, R.; Wingard, J. R.; Walsh, T. J.; Kontoyiannis, D. P.
Article Title: Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006
Abstract: Recent reports describe increasing incidence of non- Aspergillus mold infections in hematopoietic cell transplant (HCT) and solid organ transplant (SOT) recipients. To investigate the epidemiology of infections with Mucorales, Fusarium spp., and Scedosporium spp. molds, we analyzed data from the Transplant-Associated Infection Surveillance Network, 23 transplant centers that conducted prospective surveillance for invasive fungal infections during 2001-2006. We identifled 169 infections (105 Mucorales, 37 Fusarium spp., and 27 Scedosporium spp.) in 169 patients; 124 (73.4%) were in HCT recipients, and 45 (26.6%) were in SOT recipients. The crude 90-day mortality rate was 56.6%. The 12-month mucormycosis cumulative incidence was 0.29% for HCT and 0.07% for SOT. Mucormycosis incidence among HCT recipients varied widely, from 0.08% to 0.69%, with higher incidence in cohorts receiving transplants during 2003 and 2004. Non-Aspergillus mold infections continue to be associated with high mortality rates. The incidence of mucormycosis in HCT recipients increased substantially during the surveillance period.
Journal Title: Emerging Infectious Diseases
Volume: 17
Issue: 10
ISSN: 1080-6040
Publisher: Centers for Disease Control and Prevention  
Date Published: 2011-10-01
Start Page: 1855
End Page: 1864
Language: English
DOI: 10.3201/eid1710.110087
PROVIDER: scopus
PUBMED: 22000355
PMCID: PMC3311117
DOI/URL:
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 2 November 2011" - "CODEN: EIDIF" - "Source: Scopus"
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