Understanding the molecular circuitry of cell lineage specification in the early mouse embryo Journal Article
| Authors: | Bergsmedh, A.; Donohoe, M. E.; Hughes, R. A.; Hadjantonakis, A. K. |
| Article Title: | Understanding the molecular circuitry of cell lineage specification in the early mouse embryo |
| Abstract: | Pluripotent stem cells hold great promise for cell-based therapies in regenerative medicine. However, critical to understanding and exploiting mechanisms of cell lineage specification, epigenetic reprogramming, and the optimal environment for maintaining and differentiating pluripotent stem cells is a fundamental knowledge of how these events occur in normal embryogenesis. The early mouse embryo has provided an excellent model to interrogate events crucial in cell lineage commitment and plasticity, as well as for embryo-derived lineage-specific stem cells and induced pluripotent stem (iPS) cells. Here we provide an overview of cell lineage specification in the early (preimplantation) mouse embryo focusing on the transcriptional circuitry and epigenetic marks necessary for successive differentiation events leading to the formation of the blastocyst. © 2011 by the authors; licensee MDPI, Basel, Switzerland. |
| Keywords: | signal transduction; unclassified drug; dna binding protein; review; nonhuman; nonhistone protein; animal cell; mouse; animal tissue; somatic cell; transcription factor gata 3; gene expression; embryo; transcription initiation; sonic hedgehog protein; animal experiment; cell fate; embryo development; embryology; genetic transcription; cell lineage; rna; gene activation; dna; protein processing; transcription regulation; epigenetics; histone; nucleotide sequence; stem cells; gene control; gene regulatory network; pluripotent stem cell; ips; zinc finger protein; transcription factor yap1; octamer transcription factor 4; transcription factor sox2; lysine; arginine; placenta; protein methylation; transcription factor nanog; endoderm; preimplantation embryo; chromosome segregation; mouse embryo; chromatin structure; blastocyst; transcription factor cdx2; blastomere; mother fetus relationship; enhancer region; nucleosome; beta globin; transcription factor gata 4; transcription factor gata 6; transcription factor sox17; transcription factor sox7; inner cell mass; ectoderm; myometrium; nidation; eomesodermin; lineage specification; early development; epigenetic marks; transcriptional circuitry; chromatin assembly factor 1; lysine specific demethylase 1; morula |
| Journal Title: | Genes |
| Volume: | 2 |
| Issue: | 3 |
| ISSN: | 2073-4425 |
| Publisher: | MDPI |
| Date Published: | 2011-01-01 |
| Start Page: | 420 |
| End Page: | 448 |
| Language: | English |
| DOI: | 10.3390/genes2030420 |
| PROVIDER: | scopus |
| PMCID: | PMC3927619 |
| PUBMED: | 24710206 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 November 2011" - "Molecular Sequence Numbers: GENBANK: DK084391, HD052115;" - "Source: Scopus" |
