T cell engaging bispecific antibody (T-BsAb): From technology to therapeutics Journal Article
| Authors: | Wu, Z.; Cheung, N. V. |
| Article Title: | T cell engaging bispecific antibody (T-BsAb): From technology to therapeutics |
| Abstract: | Harnessing the power of the human immune system to treat cancer is the essence of immunotherapy. Monoclonal antibodies engage the innate immune system to destroy targeted cells. For the last 30 years, antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity have been the main mechanisms of anti-tumor action of unconjugated antibody drugs. Efforts to exploit the potentials of other immune cells, in particular T cells, culminated in the recent approval of two T cell engaging bispecific antibody (T-BsAb) drugs, thereby stimulating new efforts to accelerate similar platforms through preclinical and clinical trials. In this review, we have compiled the worldwide effort in exploring T cell engaging bispecific antibodies. Our special emphasis is on the lessons learned, with the hope to derive insights in this fast evolving field with tremendous clinical potential. © 2017 Elsevier Inc. |
| Keywords: | survival; review; t lymphocyte; cancer immunotherapy; tumor antigen; monoclonal antibody; antigen; epitope; technology; cytokine release syndrome; cd3 antibody; bispecific antibody; human; priority journal; bispecific antibodies; potency of bispecific antibodies; tdcc; bivalent cd3 binding; t cell engaging bispecific antibodies |
| Journal Title: | Pharmacology & Therapeutics |
| Volume: | 182 |
| ISSN: | 0163-7258 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2018-02-01 |
| Start Page: | 161 |
| End Page: | 175 |
| Language: | English |
| DOI: | 10.1016/j.pharmthera.2017.08.005 |
| PUBMED: | 28834699 |
| PROVIDER: | scopus |
| PMCID: | PMC5785550 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 3 December 2018 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work