Emerging tissue and blood-based biomarkers that may predict response to immune checkpoint inhibition Journal Article
| Authors: | Friedman, C. F.; Postow, M. A. |
| Article Title: | Emerging tissue and blood-based biomarkers that may predict response to immune checkpoint inhibition |
| Abstract: | The immune system plays an essential role in the surveillance and eradication of neoplastic cells. This interaction is modulated via immunologic regulators (checkpoints). Antibodies that block the checkpoints cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), and the programmed cell death protein 1 pathway (PD1/PD-L1) have demonstrated efficacy in a number of malignancies. However, response rates are variable, and administration of these antibodies can be associated with immune-related adverse events. Therefore, researchers are engaged in an effort to discover biomarkers that may predict response to these agents. This review focuses on potential blood and tumor-based biomarkers that have been assessed in patients treated with these checkpoint-blocking antibodies. © 2016, Springer Science+Business Media New York. |
| Keywords: | biomarkers; ipilimumab; melanoma; immunotherapy; ctla-4; pd-1; pd-l1; checkpoint blockade; nivolumab; pembrolizumab; neoantigens |
| Journal Title: | Current Oncology Reports |
| Volume: | 18 |
| Issue: | 4 |
| ISSN: | 1523-3790 |
| Publisher: | Springer |
| Date Published: | 2016-04-01 |
| Start Page: | 1 |
| End Page: | 7 |
| Language: | English |
| DOI: | 10.1007/s11912-016-0509-x |
| PROVIDER: | scopus |
| PUBMED: | 26922327 |
| PMCID: | PMC5063308 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 4 April 2016 -- Source: Scopus |
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