Acute myeloid leukemia targets for bispecific antibodies Journal Article
| Authors: | Hoseini, S. S.; Cheung, N. K. |
| Article Title: | Acute myeloid leukemia targets for bispecific antibodies |
| Abstract: | Despite substantial gains in our understanding of the genomics of acute myelogenous leukemia (AML), patient survival remains unsatisfactory especially among the older age group. T cell-based therapy of lymphoblastic leukemia is rapidly advancing; however, its application in AML is still lagging behind. Bispecific antibodies can redirect polyclonal effector cells to engage chosen targets on leukemia blasts. When the effector cells are natural-killer cells, both antibody-dependent and antibody-independent mechanisms could be exploited. When the effectors are T cells, direct tumor cytotoxicity can be engaged followed by a potential vaccination effect. In this review, we summarize the AML-associated tumor targets and the bispecific antibodies that have been studied. The potentials and limitations of each of these systems will be discussed. © The Author(s) 2017. |
| Journal Title: | Blood Cancer Journal |
| Volume: | 7 |
| Issue: | 2 |
| ISSN: | 2044-5385 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2017-02-24 |
| Start Page: | e522 |
| Language: | English |
| DOI: | 10.1038/bcj.2017.2 |
| PROVIDER: | scopus |
| PUBMED: | 28157217 |
| PMCID: | PMC5386336 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 2 March 2017 -- Source: Scopus |
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