Dietary intake is associated with risk of multiple myeloma and its precursor disease Journal Article


Authors: Thordardottir, M.; Lindqvist, E. K.; Lund, S. H.; Costello, R.; Burton, D.; Steingrimsdottir, L.; Korde, N.; Mailankody, S.; Eiriksdottir, G.; Launer, L. J.; Gudnason, V.; Harris, T. B.; Landgren, O.; Torfadottir, J. E.; Kristinsson, S. Y.
Article Title: Dietary intake is associated with risk of multiple myeloma and its precursor disease
Abstract: The etiology of monoclonal gammopathy of undetermined significance (MGUS), the precursor state of multiple myeloma (MM), is mostly unknown and no studies have been conducted on the effect of diet on MGUS or progression from MGUS to MM. We aimed to explore the association between common foods and MGUS and progression to MM. Data from the population-based AGES Study (N = 5,764) were utilized. Food frequency questionnaire was used to assess dietary intake during adolescence, midlife, and late life. Serum protein electrophoresis and serum free light-chain assay was performed to identify MGUS (n = 300) and LC-MGUS cases (n = 275). We cross linked our data with the Icelandic Cancer Registry to find cases of MM in the study group. We found that intake of fruit at least three times per week during adolescence was associated with lower risk of MGUS when compared to lower fruit consumption (OR = 0.62, 95% CI 0.41-0.95). We additionally found that intake of fruit at least three times per week during the late life period was associated with decreased risk of progressing from MGUS toMM (HR = 0.34, 95% CI 0.13-0.89) when compared to lower intake. Adolescent intake of fruit may reduce risk of MGUS, whereas fruit intake after MGUS onset may reduce risk of progressing to MM. Our findings suggest that diet might alter the risk of developing MGUS and progression to MM. © 2018 Thordardottir et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal Title: PLoS ONE
Volume: 13
Issue: 11
ISSN: 1932-6203
Publisher: Public Library of Science  
Date Published: 2018-11-01
Start Page: e0206047
Language: English
DOI: 10.1371/journal.pone.0206047
PUBMED: 30383820
PROVIDER: scopus
PMCID: PMC6211667
DOI/URL:
Notes: Article -- Export Date: 3 December 2018 -- Source: Scopus
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MSK Authors
  1. Carl Ola Landgren
    198 Landgren
  2. Neha Sanat Korde
    64 Korde