Dietary risk factors for monoclonal gammopathy of undetermined significance in a racially diverse population Journal Article
| Authors: | Joseph, J. M.; Hillengass, J.; Tang, L.; Lesokhin, A. M.; Landgren, O.; Usmani, S. Z.; Moysich, K. B.; McCann, S. E.; Shah, U. A. |
| Article Title: | Dietary risk factors for monoclonal gammopathy of undetermined significance in a racially diverse population |
| Abstract: | Monoclonal gammopathy of undetermined significance (MGUS), a precursor of multiple myeloma, is associated with shorter lifespan and cardiac, renal, neurologic, and immune-related comorbidities. There is little known about modifiable risk factors for this condition. To determine whether the risk of MGUS is associated with dietary factors in a racially diverse population, we conducted a US population–based case-control study from the National Health and Nutrition Examination Survey (1988-2004), which included 373 individuals with MGUS and 1406 matched controls. Diet was characterized by one 24-hour dietary recall, with gram intake of individual foods and beverages aggregated into groups. Unconditional multivariable logistic regressions were used to model associations between intake of several food groups and MGUS, with odds ratios (ORs) and 95% confidence intervals (CIs) reported for the highest relative to the lowest quantile of intake. Daily gram intake of several food and beverage groups were significantly associated with MGUS. MGUS was inversely associated with whole-grain bread, oats, and rice (OR, 0.70; 95% CI, 0.48-1.00; P < .05), fruits (excluding juice) and vegetables (OR, 0.69; 95% CI, 0.52-0.93; P = .02), vegetables (OR, 0.75; 95% CI, 0.56-0.99; P < .05), tomatoes (OR, 0.72; 95% CI, 0.51-1.00; P < .05), and cruciferous vegetables (OR, 0.44; 95% CI, 0.26-0.74; P < .01). Direct associations were observed for sugar-sweetened beverages (OR, 1.34; 95% CI, 1.00-1.78; P < .05), sugar-sweetened soft drinks (OR, 1.41; 95% CI, 1.01-1.96; P = .04), and artificially sweetened soft drinks (OR, 1.55; 95% CI, 1.04-2.33; P = .03). Our study shows that diet is potentially a modifiable risk factor for MGUS. © 2024 by The American Society of Hematology. |
| Keywords: | controlled study; aged; major clinical study; case control study; cancer risk; multiple myeloma; kidney disease; smoking; risk factor; food intake; diet; body mass; food frequency questionnaire; cardiovascular disease; comorbidity; vitamin supplementation; fruit; vegetable; physical activity; student t test; meat; whole grain; tea; milk; egg; human; male; female; article; monoclonal gammopathy of undetermined significance; bread; household income; rice; sugar-sweetened beverage; oat; soft drink |
| Journal Title: | Blood Advances |
| Volume: | 8 |
| Issue: | 3 |
| ISSN: | 2473-9529 |
| Publisher: | American Society of Hematology |
| Date Published: | 2024-02-13 |
| Start Page: | 538 |
| End Page: | 548 |
| Language: | English |
| DOI: | 10.1182/bloodadvances.2023011608 |
| PUBMED: | 38055924 |
| PROVIDER: | scopus |
| PMCID: | PMC10835229 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is Urvi A. Shah -- Source: Scopus |
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