Bone marrow aspirate and biopsy: A pathologist's perspective. II. Interpretation of the bone marrow aspirate and biopsy Journal Article


Authors: Riley, R. S.; Williams, D.; Ross, M.; Zhao, S.; Chesney, A.; Clark, B. D.; Ben-Ezra, J. M.
Article Title: Bone marrow aspirate and biopsy: A pathologist's perspective. II. Interpretation of the bone marrow aspirate and biopsy
Abstract: Bone marrow examination has become increasingly important for the diagnosis and treatment of hematologic and other illnesses. Morphologic evaluation of the bone marrow aspirate and biopsy has recently been supplemented by increasingly sophisticated ancillary assays, including immunocytochemistry, cytogenetic analysis, flow cytometry, and molecular assays. With our rapidly expanding knowledge of the clinical and biologic diversity of leukemia and other hematologic neoplasms, and an increasing variety of therapeutic options, the bone marrow examination has became more critical for therapeutic monitoring and planning optimal therapy. Sensitive molecular techniques, in vitro drug sensitivity testing, and a number of other special assays are available to provide valuable data to assist these endeavors. Fortunately, improvements in bone marrow aspirate and needle technology has made the procurement of adequate specimens more reliable and efficient, while the use of conscious sedation has improved patient comfort. The procurement of bone marrow specimens was reviewed in the first part of this series. This paper specifically addresses the diagnostic interpretation of bone marrow specimens and the use of ancillary techniques. © 2009 Wiley-Liss, Inc.
Keywords: immunohistochemistry; leukemia; review; treatment planning; flow cytometry; bone marrow; patient monitoring; pathology; monoclonal antibodies; in situ hybridization; bone marrow biopsy; diagnostic value; immunocytochemistry; biopsy, needle; biopsy, fine-needle; hematopoietic stem cells; morphometrics; chromosome analysis; karyotyping; cytochemistry; pathologist; hematologic disease; bone marrow examination; staining and labeling; bone marrow pathology; hematological diagnosis; erythrocyte structure; leukocyte structure; hematologic diseases
Journal Title: Journal of Clinical Laboratory Analysis
Volume: 23
Issue: 5
ISSN: 0887-8013
Publisher: Wiley Liss  
Date Published: 2009-01-01
Start Page: 259
End Page: 307
Language: English
DOI: 10.1002/jcla.20305
PUBMED: 19774631
PROVIDER: scopus
DOI/URL:
Notes: --- - "Export Date: 30 November 2010" - "CODEN: JCANE" - "Source: Scopus"
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  1. Bradly D Clark
    15 Clark