Trends in bone marrow sampling and core biopsy specimen adequacy in the United States and Canada: A multicenter study Journal Article
| Authors: | Merzianu, M.; Groman, A.; Hutson, A.; Cotta, C.; Brynes, R. K.; Orazi, A.; Reddy, V.; Teruya-Feldstein, J.; Amre, R.; Balasubramanian, M.; Brandao, G.; Cherian, S.; Courville, E.; Czuchlewski, D.; Fan, G.; Grier, D.; Hoehn, D.; Inamdar, K. V.; Juskevicius, R.; Kaur, P.; Lazarchick, J.; Lewis, M. R.; Miles, R. R.; Myers, J. B.; Nasr, M. R.; Qureishi, H. N.; Olteanu, H.; Robu, V. G.; Salaru, G.; Vajpayee, N.; Vos, J.; Zhang, L.; Zhang, S.; Aye, L.; Brega, E.; Coad, J. E.; Grantham, J.; Ivelja, S.; McKenna, R.; Sultan, K.; Wilding, G.; Hutchison, R.; Peterson, L.; Cheney, R. T. |
| Article Title: | Trends in bone marrow sampling and core biopsy specimen adequacy in the United States and Canada: A multicenter study |
| Abstract: | Objectives: To assess bone marrow (BM) sampling in academic medical centers. Methods: Data from 6,374 BM samples obtained in 32 centers in 2001 and 2011, including core length (CL), were analyzed. Results: BM included a biopsy (BMB; 93%) specimen, aspirate (BMA; 92%) specimen, or both (83%). The median (SD) CL was 12 (8.5) mm, and evaluable marrow was 9 (7.6) mm. Tissue contraction due to processing was 15%. BMB specimens were longer in adults younger than 60 years, men, and bilateral, staging, and baseline samples. Only 4% of BMB and 2% of BMB/BMA samples were deemed inadequate for diagnosis. BM for plasma cell dyscrasias, nonphysician operators, and ancillary studies usage increased, while bilateral sampling decreased over the decade. BM-related quality assurance programs are infrequent. Conclusions: CL is shorter than recommended and varies with patient age and sex, clinical circumstances, and center experience. While pathologists render diagnoses on most cases irrespective of CL, BMB yield improvement is desirable. © 2018 American Society for Clinical Pathology. All rights reserved. |
| Keywords: | bone marrow biopsy; bone marrow adequacy; bone marrow biopsy indications; bone marrow quality; core biopsy length |
| Journal Title: | American Journal of Clinical Pathology |
| Volume: | 150 |
| Issue: | 5 |
| ISSN: | 0002-9173 |
| Publisher: | Oxford University Press |
| Date Published: | 2018-11-01 |
| Start Page: | 393 |
| End Page: | 405 |
| Language: | English |
| DOI: | 10.1093/ajcp/aqy066 |
| PUBMED: | 30052721 |
| PROVIDER: | scopus |
| PMCID: | PMC6166687 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 November 2018 -- Source: Scopus |
