Pharmacologic management of cancer pain Conference Paper


Author: Portenoy, R. K.
Title: Pharmacologic management of cancer pain
Conference Title: Cleveland Clinic Foundation CME Program on Chemotherapeutic and Nonchemotherapeutic Palliative Approaches in the Treatment of Cancer
Abstract: More than three quarters of cancer patients experience chronic pain during the course of their disease. With optimal pharmacotherapy alone, 70% to 90% could achieve adequate relief. Optimal pharmacotherapy begins with a comprehensive pain assessment, which defines the nature of the pain complaint and clarifies the degree to which pain and other factors contribute to impaired quality of life. Although the potential analgesic consequences of primary therapy are always considered, only radiotherapy is used commonly. Patients with persistent moderate to severe pain should be treated with an appropriate opioid regimen, which is based on careful selection of an opioid drug and route of administration, individualization of the dose through titration based on repeated assessment of the patient, and ongoing efforts to manage side effects. The use of adjuvant analgesics and the use of sequential opioid trials may improve the outcome of therapy for patients who fail to promptly attain a favorable balance between analgesia and side effects during an opioid trial.
Keywords: treatment planning; conference paper; neoplasms; palliative care; quality of life; pain; cancer pain; chronic disease; disease severity; paracetamol; nonsteroid antiinflammatory agent; anti-inflammatory agents, non-steroidal; drug response; methadone; morphine; analgesics, opioid; relaxation training; hydromorphone; analgesia; dose calculation; intravenous drug administration; analgesic agent; fentanyl; levorphanol; oxycodone; nerve block; oral drug administration; codeine; dextropropoxyphene; cordotomy; subcutaneous drug administration; human; priority journal; rhizotomy; orthotics
Journal Title Seminars in Oncology
Volume: 22
Issue: 2 Suppl. 3
Conference Dates: 1994 Apr 29-30
Conference Location: Cleveland, OH
ISBN: 0093-7754
Publisher: Elsevier Inc.  
Date Published: 1995-04-01
Start Page: 112
End Page: 120
Language: English
PUBMED: 7537897
PROVIDER: scopus
DOI/URL:
Notes: Conference Paper -- Export Date: 28 August 2018 -- Source: Scopus
Citation Impact
MSK Authors
  1. Russell K. Portenoy
    154 Portenoy
Related MSK Work