Suppression of heat-induced hsp70 expression by the 70-kDa subunit of the human Ku autoantigen Journal Article
| Authors: | Li, G. C.; Yang, S. H.; Kim, D.; Nussenzweig, A.; Ouyang, H.; Wei, J.; Burgman, P.; Li, L. |
| Article Title: | Suppression of heat-induced hsp70 expression by the 70-kDa subunit of the human Ku autoantigen |
| Abstract: | Expression of the 70-kDa polypeptide of human Ku autoantigen in rat cells is shown to suppress specifically the induction of hsp70 upon heat shock. Thermal induction of other heat shock proteins is not significantly affected, nor is the state of phosphorylation or the DNA-binding ability of the heat shock transcription factor HSF1. These findings support a model in which hsp70 gene expression is controlled by a second regulatory factor in addition to the positive activator HSF1. The Ku autoantigen, or a protein closely related to it, is likely to be involved in the regulation of hsp70 expression. |
| Keywords: | unclassified drug; nonhuman; animal cell; protein dna binding; transcription factor; animalia; regulatory mechanism; rat; fibroblast; protein induction; autoantigen; ku antigen; stable expression; protein synthesis inhibition; protein synthesis regulation; gene regulation; heat shock protein; priority journal; article; heat stress |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 92 |
| Issue: | 10 |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Date Published: | 1995-05-09 |
| Start Page: | 4512 |
| End Page: | 4516 |
| Language: | English |
| DOI: | 10.1073/pnas.92.10.4512 |
| PUBMED: | 7753835 |
| PROVIDER: | scopus |
| PMCID: | PMC41974 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
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