Interleukin-6 stimulates gluconeogenesis in primary cultures of rat hepatocytes Journal Article

  


Authors: Blumberg, D.; Hochwald, S.; Brennan, M. F.; Burt, M.
Article Title: Interleukin-6 stimulates gluconeogenesis in primary cultures of rat hepatocytes
Abstract: Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and IL-1 have been shown to stimulate the synthesis of acute-phase proteins; however, few studies have examined the effect of these cytokines on gluconeogenesis. We investigated the effects of these cytokines on gluconeogenesis in primary cultures of rat hepatocytes. Incubation of hepatocytes for 24 hours with TNF-α or IL-1α did not affect gluconeogenesis. Hepatocytes incubated with 100 pmol/L and 1 nmol/L IL-6 had a dose-dependent increase (P < .05) in gluconeogenesis (2.6 ± 0.1 and 3.2 ± 0.1 pmol/106 cells/min, respectively) as compared with controls (2.0 ± 0.1). © 1995.
Keywords: controlled study; nonhuman; animal cell; animal; cell viability; cells, cultured; liver; tumor necrosis factor alpha; rat; interleukin 6; interleukin-6; stress; immunomodulation; glucose; rats; liver cell; culture media; tumor necrosis factor; rats, inbred f344; interleukin 1; interleukin-1; acute phase response; gluconeogenesis; acute phase protein; male; priority journal; article
Journal Title: Metabolism
Volume: 44
Issue: 2
ISSN: 0026-0495
Publisher: Elsevier Inc.  
Date Published: 1995-02-01
Start Page: 145
End Page: 146
Language: English
DOI: 10.1016/0026-0495(95)90255-4
PUBMED: 7869907
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028928722&doi=10.1016%2f0026-0495%2895%2990255-4&partnerID=40&md5=ea600742a0e42e2c3153f01eaf200970
Notes: Article -- Export Date: 28 August 2018 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Murray F Brennan
    1059 Brennan
  2. David Blumberg
    21 Blumberg
  3. Steven N Hochwald
    47 Hochwald
  4. Michael E. Burt
    187 Burt
Related MSK Work