Systemic and liver cytokine activation: Implications for liver regeneration and posthepatectomy endotoxemia and sepsis Journal Article
| Authors: | Enayati, P.; Brennan, M. F.; Fong, Y. |
| Article Title: | Systemic and liver cytokine activation: Implications for liver regeneration and posthepatectomy endotoxemia and sepsis |
| Abstract: | Hepatectomy elicits a circulating cytokine response without effects on liver IL-6 or TNF-α production. However, cytokine defense mechanisms are intact during noncomplicated liver regeneration, as indicated by normal TNF-α and IL-6 responses to endotoxemia or sepsis. Endotoxemia is a more potent stimulus for liver cytokine production than local trauma or liver regeneration, suggesting that not only the proximity to injury but also the severity and mechanisms of injury determine local cytokine responses. (Arch Surg. 1994;129:1159-1164). © 1994, American Medical Association. All rights reserved. |
| Keywords: | controlled study; nonhuman; conference paper; polymerase chain reaction; animal; animal experiment; animal model; postoperative complication; cytokine; liver; immune response; molecular sequence data; tumor necrosis factor alpha; escherichia coli; rat; interleukin 6; interleukin-6; liver resection; postoperative infection; sepsis; base sequence; hepatectomy; rats; liver regeneration; protein determination; tumor necrosis factor; rats, inbred f344; endotoxemia; endotoxins; male; priority journal; toxemia; escherichia coli endotoxin |
| Journal Title: | Archives of Surgery |
| Volume: | 129 |
| Issue: | 11 |
| ISSN: | 0004-0010 |
| Publisher: | American Medical Association |
| Date Published: | 1994-11-01 |
| Start Page: | 1159 |
| End Page: | 1164 |
| Language: | English |
| DOI: | 10.1001/archsurg.1994.01420350057006 |
| PROVIDER: | scopus |
| PUBMED: | 7979948 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- Source: Scopus |
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