Syntheses of colchicine and isocolchicine labelled with carbon‐11 or carbon‐13 Journal Article
| Authors: | Kothari, P. J.; Finn, R. D.; Larson, S. M. |
| Article Title: | Syntheses of colchicine and isocolchicine labelled with carbon‐11 or carbon‐13 |
| Abstract: | The syntheses of isotopically labelled (−)‐10‐[11C/13C]‐colchicine and (−)‐9‐[11C/13C]‐ isocolchicine have been achieved from the reaction of (−)desmethylcolchicine with [11C/13C]‐iodomethane. The radiolabelled compounds, (−)‐10‐[11C]‐colchicine (11C‐n‐colchicine) and (−)‐9‐[11C]‐isocolchicine (11C‐i‐colchicine), were isolated by reversed phase HPLC. The total synthesis time was approximately 60 minutes for both radiolabelled compounds with an average specific activity of 240 mCi/μmol calculated to EOB. Utilizing a similar synthetic strategy, we also report the synthesis of milligram quantities of the carbon‐13 enriched compounds and the magnetic resonance signal assignment for (−)‐9‐[13C] isocolchicine. Copyright © 1995 John Wiley & Sons, Ltd. |
| Keywords: | drug synthesis; isotope labeling; colchicine; carbon 11; reversed phase high performance liquid chromatography; article; 11c/13c‐iodomethane; magnetic resonance imaging(mri); positron emission tomography(pet); [11c/13c]‐i‐colchicine; [11c/13c]‐n‐colchicine; isocolchicine |
| Journal Title: | Journal of Labelled Compounds and Radiopharmaceuticals |
| Volume: | 36 |
| Issue: | 6 |
| ISSN: | 0362-4803 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1995-06-01 |
| Start Page: | 521 |
| End Page: | 528 |
| Language: | English |
| DOI: | 10.1002/jlcr.2580360603 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
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