On the introduction of a trifluoromethyl substituent in the epothilone setting: Chemical issues related to ring forming olefin metathesis and earliest biological findings Journal Article

  

Authors:	Rivkin, A.; Biswas, K.; Chou, T. C.; Danishefsky, S. J.
Article Title:	On the introduction of a trifluoromethyl substituent in the epothilone setting: Chemical issues related to ring forming olefin metathesis and earliest biological findings
Abstract:	(matrix presented) The disclosure herein describes the synthesis of 10,11-dehydro-13,14-desoxy-27-trifluoro-[17]epothilone B via a stereoselective ring-closing metathesis and provides early biological evaluation data pertinent to this compound.
Keywords:	cell division; drug effect; tumor cells, cultured; chemistry; cell culture; chemical structure; molecular structure; synthesis; indicators and reagents; alkene; alkenes; dyes, reagents, indicators, markers and buffers; humans; human; article
Journal Title:	Organic Letters
Volume:	4
Issue:	23
ISSN:	1523-7060
Publisher:	American Chemical Society
Date Published:	2002-11-14
Start Page:	4081
End Page:	4084
Language:	English
DOI:	10.1021/ol0268283
PUBMED:	12423091
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-0037078811&partnerID=40&md5=33c060ec7cadef91630947429a71340c
Notes:	Export Date: 14 November 2014 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/66897