Enediyne quinone imines: Truncated, biologically active dynemicin congeners Journal Article

  


Authors: Shair, M. D.; Yoon, T.; Chou, T. C.; Danishefsky, S. J.
Article Title: Enediyne quinone imines: Truncated, biologically active dynemicin congeners
Abstract: An intermediate in the total synthesis of dynemicin A, quinone imine 1 can be used as a dienophile. But 1 is also a potent cytotoxic agent against human cancer cell lines since it is able to cleave DNA. In vitro and in vivo studies showed that 1 is more effective than two frequently applied antitumor drugs. Quinone imine 1 was synthesized by the rapid oxidation of a fleeting hydroisoquinone intermediate. (Figure Presented.) Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany
Journal Title: Angewandte Chemie: International Edition in English
Volume: 33
Issue: 23-24
ISSN: 0570-0833
Publisher: Wiley - V C H Verlag GmbH & Co. KGaA  
Date Published: 1995-01-03
Start Page: 2477
End Page: 2479
Language: English
DOI: 10.1002/anie.199424771
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-33751144977&doi=10.1002%2fanie.199424771&partnerID=40&md5=57918d7d4282c01449295a5d02f31cd8
Notes: Article -- Export Date: 28 August 2018 -- Source: Scopus
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MSK Authors
  1. Samuel J Danishefsky
    539 Danishefsky
  2. Ting-Chao Chou
    319 Chou
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