MRI liver fat quantification in an oncologic population: The added value of complex chemical shift-encoded MRI Journal Article

Authors: Corrias, G.; Krebs, S.; Eskreis-Winkler, S.; Ryan, D.; Zheng, J.; Capanu, M.; Saba, L.; Monti, S.; Fung, M.; Reeder, S.; Mannelli, L.
Article Title: MRI liver fat quantification in an oncologic population: The added value of complex chemical shift-encoded MRI
Abstract: Introduction: Chemotherapy prolongs the survival of patients with advanced and metastatic tumors. Since the liver plays an active role in the metabolism of chemotherapy agents, hepatic injury is a common adverse effect. The purpose of this study is to compare a novel quantitative chemical shift encoded magnetic resonance imaging (CSE-MRI) method with conventional T1-weighted In and Out of phase (T1 IOP) MR for evaluating the reproducibility of the methods in an oncologic population exposed to chemotherapy. Materials and methods: This retrospective study was approved by the institutional review board with a waiver for informed consent. The study included patients who underwent chemotherapy, no suspected liver iron overload, and underwent upper abdomen MRI. Two radiologists independently draw circular ROIsin the liver parenchyma. The fat fraction was calculated from IOP imaging and measured from IDEAL-IQ fat fraction maps. Two different equations were used to estimate fat with IOP sequences. Intra-class correlation coefficient and repeatability coefficient were estimated to evaluate agreement between two readers on iron level and fat fraction measurement. Results: CSE-MRI showed a higher reliability in fat quantification compared with both IOP methods, with a substantially higher inter-reader agreement (0.961 vs 0.372). This has important clinical implications. Conclusion: The novel CSE-MRI method described here provides increased reproducibility and confidence in diagnosing hepatic steatosis in a oncologic clinical setting. IDEAL-IQ has been proved to be more reproducible than conventional IOP imaging. © 2018 Elsevier Inc.
Keywords: adult; cancer chemotherapy; controlled study; aged; major clinical study; cancer patient; chemotherapy; nuclear magnetic resonance imaging; magnetic resonance imaging; reproducibility; enzyme inhibition; retrospective study; liver; correlation coefficient; diagnostic value; quantitative analysis; diagnosis; iron; intermethod comparison; liver parenchyma; fatty liver; oncologic imaging; chemical shift; human; male; female; priority journal; article; hepatic steatosis; measurement repeatability; reproducibilities; institutional review boards; fat fraction; ideal-iq; pdff; chemotherapy agents; fraction measurements; chemical shift encoded magnetic resonance imaging; in phase and opposed phase imaging; iterative decomposition of water and fat with echo asymmetry and least squares estimation
Journal Title: Clinical Imaging
Volume: 52
ISSN: 0899-7071
Publisher: Elsevier Inc.  
Date Published: 2018-11-01
Start Page: 193
End Page: 199
Language: English
DOI: 10.1016/j.clinimag.2018.08.002
PROVIDER: scopus
PUBMED: 30103108
Notes: Article -- Export Date: 4 September 2018 -- Source: Scopus
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MSK Authors
  1. Junting Zheng
    128 Zheng
  2. Marinela Capanu
    189 Capanu
  3. Simone Susanne Krebs
    12 Krebs
  4. Davinia Elizabeth Ryan
    6 Ryan