Prognostic utility of MRI features in intradiverticular bladder tumor Journal Article
| Authors: | Woo, S.; Ghafoor, S.; Becker, A. S.; Hricak, H.; Goh, A. C.; Vargas, H. A. |
| Article Title: | Prognostic utility of MRI features in intradiverticular bladder tumor |
| Abstract: | Background: Intradiverticular bladder tumors (IDBT) are rare but clinically important, as they are difficult to assess endoscopically due to limited anatomic access and risk of perforation. MRI may be helpful in assessing IDBT and providing relevant staging and prognostic information. Purpose: To assess MRI findings of IDBT and their relationship with overall survival. Methods: This retrospective study included 31 consecutive patients with IDBT undergoing MRI from 2008 to 2018 identified through electronic medical records and PACS database search. Two radiologists independently assessed the following MRI features: size (>3 vs ≤3 cm), diverticular neck involvement, Vesical Imaging-Reporting and Data System (VI-RADS) score (>3 vs ≤3), perivesical fat infiltration, additional tumors and suspicious pelvic lymph nodes. Overall survival was estimated using Kaplan-Meier analysis; and the relationship with clinicopathological and MRI features was determined using the Cox proportional-hazards regression model. Inter-reader agreement was assessed using intraclass correlation coefficients (ICC) and Cohen's kappa (K). Results: Median follow-up was 1044 days (interquartile range, 474–1952 days). Twenty-six (83.9%) patients underwent surgical treatment with or without neoadjuvant chemotherapy. On MRI, greater tumor size (>3 cm), diverticular neck involvement, perivesical extension, and suspicious lymph nodes were associated with lower overall survival (HR = 3.6–8.1 and 4.3–6.3 for the 2 radiologists, p ≤ 0.03). Other clinicopathological or MRI findings were not associated with survival (p = 0.27–0.65). Inter-reader agreement was excellent for tumor size (ICC = 0.991; 95% CI 0.982–0.996), fair for VI-RADS (K = 0.52, 95% CI, 0.22–0.82), and moderate for others (K = 0.61–0.79). Conclusion: In patients with IDBT, several MRI features were significantly associated with overall survival. Utilizing all available clinicopathological and imaging information may improve estimation of prognosis. © 2020 The Association of University Radiologists |
| Keywords: | adult; cancer survival; clinical article; aged; survival rate; overall survival; histopathology; squamous cell carcinoma; cancer radiotherapy; cancer staging; nuclear magnetic resonance imaging; follow up; magnetic resonance imaging; cancer grading; cancer palliative therapy; adenocarcinoma; data base; retrospective study; bladder cancer; electronic medical record; adjuvant chemotherapy; cancer size; cystectomy; scoring system; sarcomatoid carcinoma; clear cell carcinoma; neoadjuvant chemotherapy; papillary carcinoma; transurethral resection; bladder surgery; transitional cell carcinoma; lymphadenopathy; myxosarcoma; interrater reliability; muscle invasive bladder cancer; tumor invasion; survival prediction; lipid storage; cystography; cancer prognosis; prognosis; human; male; female; article; bladder diverticulum; prognostic assessment; vesical imaging reporting and data system; intradiverticular bladder tumor |
| Journal Title: | Academic Radiology |
| Volume: | 29 |
| Issue: | 2 |
| ISSN: | 1076-6332 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2022-02-01 |
| Start Page: | 219 |
| End Page: | 228 |
| Language: | English |
| DOI: | 10.1016/j.acra.2020.10.010 |
| PUBMED: | 33162319 |
| PROVIDER: | scopus |
| PMCID: | PMC8096867 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 February 2022 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
419Hricak -
267Vargas Alvarez -
72Goh -
62Woo -
40Becker
Related MSK Work