The metastatic niche: Adapting the foreign soil Journal Article
| Authors: | Psaila, B.; Lyden, D. |
| Article Title: | The metastatic niche: Adapting the foreign soil |
| Abstract: | The 'seed and soil' hypothesis for metastasis sets forth the concept that a conducive microenvironment, or niche, is required for disseminating tumour cells to engraft distant sites. This Opinion presents emerging data that support this concept and outlines the potential mechanism and temporal sequence by which changes occur in tissues distant from the primary tumour. To enable improvements in the prognosis of advanced malignancy, early interventions that target both the disseminating seed and the metastatic soil are likely to be required. © 2009 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | primary tumor; review; advanced cancer; nonhuman; neoplasms; bone marrow cells; metastasis; models, biological; extracellular matrix; lymphangiogenesis; neoplasm metastasis; micrometastasis; microenvironment; tumor growth; blood vessel parameters; tumor engraftment |
| Journal Title: | Nature Reviews Cancer |
| Volume: | 9 |
| Issue: | 4 |
| ISSN: | 1474-175X |
| Publisher: | Nature Publishing Group |
| Date Published: | 2009-04-01 |
| Start Page: | 285 |
| End Page: | 293 |
| Language: | English |
| DOI: | 10.1038/nrc2621 |
| PUBMED: | 19308068 |
| PROVIDER: | scopus |
| PMCID: | PMC3682494 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 25" - "Export Date: 30 November 2010" - "CODEN: NRCAC" - "Source: Scopus" |
