Mediators of vascular remodelling co-opted for sequential steps in lung metastasis Journal Article

  

Authors:	Gupta, G. P.; Nguyen, D. X.; Chiang, A. C.; Bos, P. D.; Kim, J. Y.; Nadal, C.; Gomis, R. R.; Manova-Todorova, K.; Massague, J.
Article Title:	Mediators of vascular remodelling co-opted for sequential steps in lung metastasis
Abstract:	Metastasis entails numerous biological functions that collectively enable cancerous cells from a primary site to disseminate and overtake distant organs. Using genetic and pharmacological approaches, we show that the epidermal growth factor receptor ligand epiregulin, the cyclooxygenase COX2, and the matrix metalloproteinases 1 and 2, when expressed in human breast cancer cells, collectively facilitate the assembly of new tumour blood vessels, the release of tumour cells into the circulation, and the breaching of lung capillaries by circulating tumour cells to seed pulmonary metastasis. These findings reveal how aggressive primary tumorigenic functions can be mechanistically coupled to greater lung metastatic potential, and how such biological activities may be therapeutically targeted with specific drug combinations. ©2007 Nature Publishing Group.
Keywords:	epidermal growth factor; controlled study; protein expression; human cell; drug activity; cancer growth; nonhuman; drug targeting; mouse; animals; mice; breast cancer; lung neoplasms; epidermal growth factor receptor; animal experiment; animal model; cancer cell culture; cell line, tumor; angiogenesis; breast neoplasms; neovascularization, pathologic; cetuximab; carcinogenesis; monoclonal antibody; cancer inhibition; lung metastasis; celecoxib; cyclooxygenase 2; lung; tumor; interstitial collagenase; matrix metalloproteinase 1; ilomastat; gelatinase a; epiregulin; matrix metalloproteinase inhibitor; modeling; respiratory disease; matrix metalloproteinase 2; capillaries; prostaglandin synthase inhibitor; lung capillary
Journal Title:	Nature
Volume:	446
Issue:	7137
ISSN:	0028-0836
Publisher:	Nature Publishing Group
Date Published:	2007-04-12
Start Page:	765
End Page:	770
Language:	English
DOI:	10.1038/nature05760
PUBMED:	17429393
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-34147220392&partnerID=40&md5=6c22c7308e8dee75077283259007ddd6
Notes:	--- - "Cited By (since 1996): 186" - "Export Date: 17 November 2011" - "CODEN: NATUA" - "Source: Scopus"

https://synapse.mskcc.org/synapse/works/has_related_data_chk/17432