Metastatic stem cells: Sources, niches, and vital pathways Journal Article
| Authors: | Oskarsson, T.; Batlle, E.; Massagué, J. |
| Article Title: | Metastatic stem cells: Sources, niches, and vital pathways |
| Abstract: | Metastasis is powered by disseminated cancer cells that re-create a full-fledged tumor in unwelcoming tissues, away from the primary site. How cancer cells moving from a tumor into the circulation manage to infiltrate distant organs and initiate metastatic growth is of interest to cancer biologists and clinical oncologists alike. Recent findings have started to define the sources, phenotypic properties, hosting niches, and signaling pathways that support the survival, self-renewal, dormancy, and reactivation of cancer cells that initiate metastasis: metastatic stem cells. By dissecting the biology of this process, vulnerabilities are being exposed that could be exploited to prevent metastasis. © 2014 Elsevier Inc. |
| Keywords: | primary tumor; review; cancer growth; nonhuman; colorectal cancer; metastasis; breast cancer; gene expression; lung cancer; extracellular matrix; cytokine; probability; cell transformation; cancer cell; cancer stem cell; liver cancer; brain cancer; dormancy; epithelial mesenchymal transition; prognosis; human; priority journal; mesenchymal epithelial transition; metastatic stem cell |
| Journal Title: | Cell Stem Cell |
| Volume: | 14 |
| Issue: | 3 |
| ISSN: | 1934-5909 |
| Publisher: | Cell Press |
| Date Published: | 2014-03-01 |
| Start Page: | 306 |
| End Page: | 321 |
| Language: | English |
| DOI: | 10.1016/j.stem.2014.02.002 |
| PROVIDER: | scopus |
| PMCID: | PMC3998185 |
| PUBMED: | 24607405 |
| DOI/URL: | |
| Notes: | Cited By (since 1996):4 -- Export Date: 1 August 2014 -- Source: Scopus |
