Microenvironmental regulation of metastasis Journal Article
| Authors: | Joyce, J. A.; Pollard, J. W. |
| Article Title: | Microenvironmental regulation of metastasis |
| Abstract: | Metastasis is a multistage process that requires cancer cells to escape from the primary tumour, survive in the circulation, seed at distant sites and grow. Each of these processes involves rate-limiting steps that are influenced by non-malignant cells of the tumour microenvironment. Many of these cells are derived from the bone marrow, particularly the myeloid lineage, and are recruited by cancer cells to enhance their survival, growth, invasion and dissemination. This Review describes experimental data demonstrating the role of the microenvironment in metastasis, identifies areas for future research and suggests possible new therapeutic avenues. © 2009 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | primary tumor; review; cancer localization; nonhuman; lymph nodes; neoplasms; tumor associated leukocyte; cell survival; metastasis; bone marrow; neovascularization, pathologic; cancer invasion; cytokine; neoplastic cells, circulating; cancer cell; neoplasm metastasis; mesenchymal stem cell; immunophenotyping; bone marrow cell; microenvironment; antigens, cd; macrophages; homeostasis; stroma cell; stromal cells; cell interaction; growth factor; cell adhesion; chronic inflammation; suppressor cell; systemic circulation; tissue growth; peptide hydrolases |
| Journal Title: | Nature Reviews Cancer |
| Volume: | 9 |
| Issue: | 4 |
| ISSN: | 1474-175X |
| Publisher: | Nature Publishing Group |
| Date Published: | 2009-04-01 |
| Start Page: | 239 |
| End Page: | 252 |
| Language: | English |
| DOI: | 10.1038/nrc2618 |
| PUBMED: | 19279573 |
| PROVIDER: | scopus |
| PMCID: | PMC3251309 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 125" - "Export Date: 30 November 2010" - "CODEN: NRCAC" - "Source: Scopus" |
