Integrin signalling during tumour progression Journal Article
| Authors: | Guo, W.; Giancotti, F. G. |
| Article Title: | Integrin signalling during tumour progression |
| Abstract: | During progression from tumour growth to metastasis, specific integrin signals enable cancer cells to detach from neighbouring cells, re-orientate their polarity during migration, and survive and proliferate in foreign microenvironments. There is increasing evidence that certain integrins associate with receptor tyrosine kinases (RTKs) to activate signalling pathways that are necessary for tumour invasion and metastasis. The effect of these integrins might be especially important in cancer cells that have activating mutations, or amplifications, of the genes that encode these RTKs. |
| Keywords: | signal transduction; mitogen activated protein kinase; review; neoplasms; cell proliferation; cell survival; metastasis; gene amplification; models, biological; stress activated protein kinase; transforming growth factor beta; ubiquitin protein ligase; protein tyrosine kinase; angiogenesis; neovascularization, pathologic; cancer invasion; extracellular matrix; neoplasm metastasis; cell migration; cell movement; cell polarity; receptor protein-tyrosine kinases; tumor growth; cell adhesion; focal adhesion kinase; integrin; integrins; priority journal; very late activation antigen 2; very late activation antigen 3 |
| Journal Title: | Nature Reviews Molecular Cell Biology |
| Volume: | 5 |
| Issue: | 10 |
| ISSN: | 1471-0072 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2004-10-01 |
| Start Page: | 816 |
| End Page: | 826 |
| Language: | English |
| DOI: | 10.1038/nrm1490 |
| PROVIDER: | scopus |
| PUBMED: | 15459662 |
| DOI/URL: | |
| Notes: | Nat. Rev. Mol. Cell Biol. -- Cited By (since 1996):651 -- Export Date: 16 June 2014 -- CODEN: NRMCB -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work