Recurrent rearrangements of FOS and FOSB define osteoblastoma Journal Article
| Authors: | Fittall, M. W.; Mifsud, W.; Pillay, N.; Ye, H.; Strobl, A. C.; Verfaillie, A.; Demeulemeester, J.; Zhang, L.; Berisha, F.; Tarabichi, M.; Young, M. D.; Miranda, E.; Tarpey, P. S.; Tirabosco, R.; Amary, F.; Grigoriadis, A. E.; Stratton, M. R.; Van Loo, P.; Antonescu, C. R.; Campbell, P. J.; Flanagan, A. M.; Behjati, S. |
| Article Title: | Recurrent rearrangements of FOS and FOSB define osteoblastoma |
| Abstract: | The transcription factor FOS has long been implicated in the pathogenesis of bone tumours, following the discovery that the viral homologue, v-fos, caused osteosarcoma in laboratory mice. However, mutations of FOS have not been found in human bone-forming tumours. Here, we report recurrent rearrangement of FOS and its paralogue, FOSB, in the most common benign tumours of bone, osteoblastoma and osteoid osteoma. Combining whole-genome DNA and RNA sequences, we find rearrangement of FOS in five tumours and of FOSB in one tumour. Extending our findings into a cohort of 55 cases, using FISH and immunohistochemistry, provide evidence of ubiquitous mutation of FOS or FOSB in osteoblastoma and osteoid osteoma. Overall, our findings reveal a human bone tumour defined by mutations of FOS and FOSB. © 2018 The Author(s). |
| Keywords: | mus |
| Journal Title: | Nature Communications |
| Volume: | 9 |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2018-06-01 |
| Start Page: | 2150 |
| Language: | English |
| DOI: | 10.1038/s41467-018-04530-z |
| PROVIDER: | scopus |
| PMCID: | PMC5984627 |
| PUBMED: | 29858576 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 July 2018 -- Source: Scopus |
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