Mini-review of kidney disease following hematopoietic stem cell transplant Journal Article


Authors: Sedhom, R.; Sedhom, D.; Jaimes, E.
Article Title: Mini-review of kidney disease following hematopoietic stem cell transplant
Abstract: Advancements in hematopoietic cell transplantation (HCT) have broadened indications for its use and resulted in more long-term survivors. Stem cell transplantation is associated with several wellknown toxicities, although renal complications are not well defined. Acute and chronic kidney disease remains a common complication following transplantation itself. Incidence and risk factors for the development of chronic kidney disease (CKD) is less well understood. Recent estimates suggest that nearly 15% of subjects undergoing HCT will develop CKD, a complication that can progress to end-stage renal disease (ESRD), disrupts overall quality of life, and reduces overall survival. Several commonly-reported risk factors include acute kidney injury, graft-versus-host disease, and long-term calcineurin inhibitor use. This review highlights the incidence, timeline, etiology, risk factors, and prognosis of kidney disease in the setting of hematopoietic stem cell transplantation. Investigation of the causes of CKD is needed, as are ways to prevent, mitigate, and treat kidney injury. Renal disease importantly reflects prognosis, with dialysis-requiring patients carrying greater than 80% mortality after 3 years. Although CKD following HCT is common, prospective studies are needed to confirm risk factors and better define the underlying mechanisms in order to promote therapies that prevent this complication. © 2018 Dustri-Verlag Dr. K. Feistle.
Keywords: mortality; pathogenesis; review; kidney disease; incidence; kidney failure; hematopoietic stem cell transplantation; risk factor; acute kidney failure; chronic kidney disease; kidney injury; graft versus host reaction; allogeneic hematopoietic stem cell transplantation; intermethod comparison; hemodialysis; thrombotic thrombocytopenic purpura; autologous hematopoietic stem cell transplantation; chronic kidney failure; clinical outcome; immunoglobulin a nephropathy; renal complications; prognosis; human; kidney infection; glomerulopathy; acute kidney disease; focal glomerulosclerosis; membranous glomerulonephritis; viral nephropathy
Journal Title: Clinical Nephrology
Volume: 89
Issue: 6
ISSN: 0301-0430
Publisher: Dustri-Verlag Dr. Karl Feistle  
Date Published: 2018-06-01
Start Page: 389
End Page: 402
Language: English
DOI: 10.5414/cn109276
PROVIDER: scopus
PUBMED: 29578399
DOI/URL:
Notes: Review -- Export Date: 2 July 2018 -- Source: Scopus
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MSK Authors
  1. Edgar Alberto Jaimes
    23 Jaimes