Uptake of [(18)F]fluorodeoxyglucose in initial positron-emission tomography predicts survival in MALT lymphoma Journal Article


Authors: Qi, S.; Huang, M. Y.; Yang, Y.; Schöder, H.; Teckie, S.; Noy, A.; Chau, K.; Yahalom, J.
Article Title: Uptake of [(18)F]fluorodeoxyglucose in initial positron-emission tomography predicts survival in MALT lymphoma
Abstract: The role of [F-18] fluorodeoxyglucose (FDG) positron-emission tomography (PET) in mucosa-associated lymphoid tissue (MALT) of marginal zone lymphoma remains poorly defined. We correlated initial PET with pathology, clinical factors, and outcome. From January 2001 to July 2012, 173 MALT lymphoma patients with a biopsied lesion identified on PET within 90 days of tissue biopsy were analyzed. PET positivity and intensity of FDG uptake were correlated with clinical factors and patient outcome. Among 173 accrued cases, biopsied site was PET avid in 123 patients (71%); median standardized uptake value (SUV) was 6.0 (range: 0.7-28.0), and SUV >10.0 in 20 patients (16%). PET avidity varied by organ sites. PET positivity correlated with higher International Prognostic Index, but not with 5-year overall survival (OS; 96% vs 88%, PET negative vs positive, P = .229) or 5-year progression-free survival (67% vs 56%, P = .493). SUV was an independent prognostic factor of OS, and an increased SUV was associated with a decreasing 5-year OS. Patients who presented with SUV >= 10 had a higher rate of subsequent large cell transformation (20% vs 5%, P = .035) and inferior OS (78% vs 92%, P = .008). The exact role of FDG PET in the management of MALT lymphoma, beyond initial staging, remains to be defined.
Keywords: classification; experience; fdg-pet; follicular lymphoma; response assessment; non-hodgkins-lymphoma; b-cell lymphoma; 18f-fdg pet/ct; indolent; tissue lymphoma
Journal Title: Blood Advances
Volume: 2
Issue: 6
ISSN: 2473-9529
Publisher: American Society of Hematology  
Date Published: 2018-03-27
Start Page: 649
End Page: 655
Language: English
ACCESSION: WOS:000428386900007
DOI: 10.1182/bloodadvances.2017013698
PROVIDER: wos
PMCID: PMC5873233
PUBMED: 29563121
Notes: Article -- Source: Wos
Altmetric Score
MSK Authors
  1. Joachim Yahalom
    394 Yahalom
  2. Ariela Noy
    204 Noy
  3. Heiko Schoder
    285 Schoder
  4. Sewit Teckie
    15 Teckie
  5. Shunan Qi
    8 Qi
  6. Karen Chau
    15 Chau
  7. May Yu-Ting Huang
    1 Huang