The majority of transformed lymphomas have high standardized uptake values (SUVs) on positron emission tomography (PET) scanning similar to diffuse large B-cell lymphoma (DLBCL) Journal Article
| Authors: | Noy, A.; Schoder, H.; Gonen, M.; Weissler, M.; Ertelt, K.; Cohler, C.; Portlock, C.; Hamlin, P.; Yeung, H. W. D. |
| Article Title: | The majority of transformed lymphomas have high standardized uptake values (SUVs) on positron emission tomography (PET) scanning similar to diffuse large B-cell lymphoma (DLBCL) |
| Abstract: | Background: We previously correlated non-Hodgkin's lymphoma (NHL) histology with 18 fluoro-2-deoxyglucose-positron emission tomography (FDG-PET) intensity: A standardized uptake value (SUV) >10 predicted aggressive lymphoma with >80% certainty and an SUV >13, with >90% certainty. Patients and methods: To evaluate SUV in transformed lymphoma, we identified all FDG-PET scans for NHL at Memorial Sloan-Kettering Cancer 1999-2007 with (i) biopsy-proven transformation, (ii) no therapy 60 days before PET scan and (iii) FDG-PET scans no more than 60 days before or 90 days after transformation. Results: In 5 of 40 patients, the biopsy site was excised before PET; in two, only marrow was biopsied. In the remaining 33 patients, the SUV of the biopsy site ranged from 3 to 38, mean 14, median 12. Eighteen of 33 biopsies (55%) had an SUV >10 and 16 (48%) >13. The highest SUV in a transformed lymphoma PET scan (SUV<sub>study-max</sub>) ranged from 3.2 to 40, mean 15, median 12. Twenty-five of 40 patients (63%) presented with an SUV<sub>study-max</sub> >10 and 20 (50%) >13. Conclusions: Like de novo aggressive lymphomas, the majority of transformations have a high SUV<sub>study-max</sub> for a given pretreatment staging study, although many do not have very high values. Transformation should be suspected in indolent lymphoma with high SUVs on FDG-PET. Biopsies should be directed to the site of greatest FDG avidity. © The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. |
| Keywords: | clinical article; human tissue; histopathology; positron emission tomography; cancer grading; cohort studies; biopsy; b cell lymphoma; drug uptake; bone marrow biopsy; lymphoma; fluorodeoxyglucose f 18; positron-emission tomography; large cell lymphoma; lymphoma, large b-cell, diffuse; malignant transformation; follicular lymphoma; marginal zone lymphoma; positron emission tomography (pet); <sup>18</sup>fluoro-2-deoxyglucose (fdg); standardized uptake value (suv); transformation |
| Journal Title: | Annals of Oncology |
| Volume: | 20 |
| Issue: | 3 |
| ISSN: | 0923-7534 |
| Publisher: | Oxford University Press |
| Date Published: | 2009-03-01 |
| Start Page: | 508 |
| End Page: | 512 |
| Language: | English |
| DOI: | 10.1093/annonc/mdn657 |
| PUBMED: | 19139176 |
| PROVIDER: | scopus |
| PMCID: | PMC4542578 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 30 November 2010" - "CODEN: ANONE" - "Source: Scopus" |
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