The majority of transformed lymphomas have high standardized uptake values (SUVs) on positron emission tomography (PET) scanning similar to diffuse large B-cell lymphoma (DLBCL) Journal Article


Authors: Noy, A.; Schoder, H.; Gonen, M.; Weissler, M.; Ertelt, K.; Cohler, C.; Portlock, C.; Hamlin, P.; Yeung, H. W. D.
Article Title: The majority of transformed lymphomas have high standardized uptake values (SUVs) on positron emission tomography (PET) scanning similar to diffuse large B-cell lymphoma (DLBCL)
Abstract: Background: We previously correlated non-Hodgkin's lymphoma (NHL) histology with 18 fluoro-2-deoxyglucose-positron emission tomography (FDG-PET) intensity: A standardized uptake value (SUV) &gt;10 predicted aggressive lymphoma with &gt;80% certainty and an SUV &gt;13, with &gt;90% certainty. Patients and methods: To evaluate SUV in transformed lymphoma, we identified all FDG-PET scans for NHL at Memorial Sloan-Kettering Cancer 1999-2007 with (i) biopsy-proven transformation, (ii) no therapy 60 days before PET scan and (iii) FDG-PET scans no more than 60 days before or 90 days after transformation. Results: In 5 of 40 patients, the biopsy site was excised before PET; in two, only marrow was biopsied. In the remaining 33 patients, the SUV of the biopsy site ranged from 3 to 38, mean 14, median 12. Eighteen of 33 biopsies (55%) had an SUV &gt;10 and 16 (48%) &gt;13. The highest SUV in a transformed lymphoma PET scan (SUV<sub>study-max</sub>) ranged from 3.2 to 40, mean 15, median 12. Twenty-five of 40 patients (63%) presented with an SUV<sub>study-max</sub> &gt;10 and 20 (50%) &gt;13. Conclusions: Like de novo aggressive lymphomas, the majority of transformations have a high SUV<sub>study-max</sub> for a given pretreatment staging study, although many do not have very high values. Transformation should be suspected in indolent lymphoma with high SUVs on FDG-PET. Biopsies should be directed to the site of greatest FDG avidity. © The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.
Keywords: clinical article; human tissue; histopathology; positron emission tomography; cancer grading; cohort studies; biopsy; b cell lymphoma; drug uptake; bone marrow biopsy; lymphoma; fluorodeoxyglucose f 18; positron-emission tomography; large cell lymphoma; lymphoma, large b-cell, diffuse; malignant transformation; follicular lymphoma; marginal zone lymphoma; positron emission tomography (pet); <sup>18</sup>fluoro-2-deoxyglucose (fdg); standardized uptake value (suv); transformation
Journal Title: Annals of Oncology
Volume: 20
Issue: 3
ISSN: 0923-7534
Publisher: Oxford University Press  
Date Published: 2009-03-01
Start Page: 508
End Page: 512
Language: English
DOI: 10.1093/annonc/mdn657
PUBMED: 19139176
PROVIDER: scopus
PMCID: PMC4542578
DOI/URL:
Notes: --- - "Cited By (since 1996): 4" - "Export Date: 30 November 2010" - "CODEN: ANONE" - "Source: Scopus"
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MSK Authors
  1. Carol Portlock
    181 Portlock
  2. Ariela Noy
    208 Noy
  3. Henry W D Yeung
    127 Yeung
  4. Mithat Gonen
    716 Gonen
  5. Heiko Schoder
    289 Schoder
  6. Paul Hamlin
    174 Hamlin