Sinonasal secretory carcinoma of salivary gland with high grade transformation: A case report of this under-recognized diagnostic entity with prognostic and therapeutic implications Journal Article

   

Authors:	Xu, B.; Aryeequaye, R.; Wang, L.; Katabi, N.
Article Title:	Sinonasal secretory carcinoma of salivary gland with high grade transformation: A case report of this under-recognized diagnostic entity with prognostic and therapeutic implications
Abstract:	Secretory carcinoma (SC) is a recently described salivary gland carcinoma with characteristic ETV6-NTRK3 fusion. In this case report, we described a SC of the maxillary sinus that underwent high grade transformation in a 61-year-old patient. The diagnosis was confirmed by the presence of ETV6 translocation. Within the sinonasal tract, SC is an important differential diagnosis especially of sinonasal adenocarcinoma, non-intestinal type (non-ITAC), as these two entities bears histologic and immunophenotypic similarity. Distinction between these two tumors can be challenging based on the morphology alone and may require additional immunohistochemical and molecular studies. It is important to recognize that SC can occur in the sinonasal tract as correctly diagnosing SC may be prognostic relevant and may provide new targeted therapeutic avenues for these patients. © 2017, Springer Science+Business Media, LLC.
Keywords:	high grade transformation; secretory carcinoma; etv6-ntrk3 fusion; sinonasal non-intestinal type adenocarcinoma
Journal Title:	Head and Neck Pathology
Volume:	12
Issue:	2
ISSN:	1936-055X
Publisher:	Humana Press Inc
Date Published:	2018-06-01
Start Page:	274
End Page:	278
Language:	English
DOI:	10.1007/s12105-017-0855-5
PROVIDER:	scopus
PMCID:	PMC5953877
PUBMED:	28980201
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85030544798&doi=10.1007%2fs12105-017-0855-5&partnerID=40&md5=a8caf3530193f872fa75cd6fea3fa5b3
Notes:	Article -- Export Date: 1 June 2018 -- Source: Scopus

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