FGFR1/2/3-rearranged carcinoma of the head and neck: Expanded histological spectrum crossing path with high-risk HPV in the sinonasal tract Journal Article
| Authors: | Chu, Y. H.; Mullaney, K.; DiNapoli, S. E.; Cohen, M. A.; Xu, B.; Ghossein, R.; Katabi, N.; Dogan, S. |
| Article Title: | FGFR1/2/3-rearranged carcinoma of the head and neck: Expanded histological spectrum crossing path with high-risk HPV in the sinonasal tract |
| Abstract: | Aims: Oncogenic FGFR1/2/3 rearrangements are found in various cancers. Reported cases in head and neck (HN) are mainly squamous cell carcinomas (SCCs) with FGFR3::TACC3 fusions, a subset of which also harbour high-risk human papillomavirus (HPV). However, the knowledge of the clinicopathological spectrum of FGFR-rearranged head and neck carcinomas (FHNC) is limited. Methods and results: A retrospective MSK-fusion clinical sequencing cohort 2016–23 was searched to identify malignant tumours in the HN region harbouring FGFR1/2/3 fusion. FHNC were characterised by histological examination, immunohistochemistry and molecular analysis. Electronic medical records were reviewed. Three FHNC were identified. Two cases (cases 1 and 2) involved sinonasal tract and were high-grade carcinomas with squamous, basaloid, glandular and/or ductal–myoepithelial features. Case 1 arose in a 79-year-old man and harboured FGFR2::KIF1A fusion. Case 2 arose in a 58-year-old man, appeared as HPV-related multiphenotypic sinonasal carcinoma (HMSC), and was positive for FGFR2::TACC2 fusion and concurrent high-risk HPV, non-type 16/18. Case 3 was FGFR3::TACC3 fusion-positive keratinising SCCs arising in the parotid of a 60-year-old man. All three cases presented at stage T4. Clinical follow-up was available in two cases; case 1 remained disease-free for 41 months post-treatment and case 3 died of disease 2 months after the diagnosis. Conclusions: FHNC include a morphological spectrum of carcinomas with squamous features and may occur in different HN locations, such as parotid gland and the sinonasal tract. Sinonasal cases can harbour FGFR2 rearrangement with or without associated high-risk HPV. Timely recognition of FHNC could help select patients potentially amenable to targeted therapy with FGFR inhibitors. Further studies are needed (1) to determine if FGFR2 rearranged/HPV-positive sinonasal carcinomas are biologically distinct from HMSC, and (2) to elucidate the biological and clinical significance of FGFR2 rearrangement in the context of high-risk HPV. © 2023 John Wiley & Sons Ltd. |
| Keywords: | immunohistochemistry; adult; clinical article; human tissue; aged; middle aged; retrospective studies; genetics; case report; squamous cell carcinoma; carcinoma, squamous cell; cisplatin; bone metastasis; positron emission tomography; follow up; skin defect; cohort analysis; smoking; pathology; retrospective study; fibroblast growth factor receptor 3; biopsy; histology; distant metastasis; risk; docetaxel; tissue section; in situ hybridization; oncogene; electronic medical record; whole body imaging; head and neck cancer; chromatin; gene fusion; cytoplasm; imaging; nasopharynx carcinoma; mitosis rate; calponin; adenosquamous carcinoma; salivary gland tumor; skull base; chromogranin; epistaxis; paranasal sinus neoplasms; parotid gland; hard palate; hyperlipidemia; proton radiation; nose carcinoma; paranasal sinus; paranasal sinuses; receptor, fibroblast growth factor, type 1; fibroblast growth factor receptor 1; fibroblast growth factor receptor 2; head and neck carcinoma; chemoradiotherapy; kinesin; differentiation; wart virus; papillomavirus infections; nasopharynx; synaptophysin; respiratory epithelium; paranasal sinus tumor; cervical lymphadenopathy; head and neck squamous cell carcinoma; microtubule-associated proteins; microtubule associated protein; myoepithelial carcinoma; salivary duct carcinoma; subcutaneous tissue; papillomavirus infection; anosmia; erosion; sinonasal adenocarcinoma; squamous epithelium; sinonasal carcinoma; multiplex polymerase chain reaction; high throughput sequencing; parotid; fgfr1 protein, human; fgfr2; fgfr3; humans; human; male; article; rna sequencing; fgfr1; tubulogenesis; x-ray computed tomography; nose cavity tumor; neoplastic cell transformation; kinesins; kif1a protein, human; tacc3 protein, human |
| Journal Title: | Histopathology |
| Volume: | 84 |
| Issue: | 4 |
| ISSN: | 0309-0167 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2024-03-01 |
| Start Page: | 589 |
| End Page: | 600 |
| Language: | English |
| DOI: | 10.1111/his.15099 |
| PUBMED: | 38010295 |
| PROVIDER: | scopus |
| PMCID: | PMC10872948 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PubMed record and PDF. Corresponding MSK author is Snjezana Dogan -- Source: Scopus |
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