(18)F-positron emitting/trimethine cyanine-fluorescent contrast for image-guided prostate cancer management Journal Article
| Authors: | Kommidi, H.; Guo, H.; Nurili, F.; Vedvyas, Y.; Jin, M. M.; McClure, T. D.; Ehdaie, B.; Sayman, H. B.; Akin, O.; Aras, O.; Ting, R. |
| Article Title: | (18)F-positron emitting/trimethine cyanine-fluorescent contrast for image-guided prostate cancer management |
| Abstract: | [18/19F]-4, an anionic GCPII/PSMA inhibitor for image-guided intervention in prostate cancer, is described. [19F]-4 is radiolabeled with a radiochemical yield that is ≥27% and a molar activity of 190 ± 50 mCi/μmol in a <1 h, one-step, aqueous isotopic exchange reaction. [19F]-4 allows PSMA expression to be imaged by fluorescence (FL) and [18F]-PET. PC3-PIP (PSMA-positive, EC50 = 6.74 ± 1.33 nM) cancers are specifically delineated in mice that bear 3 million (18 mg) PC3-PIP and PC3 (control, PSMA-negative) cells. Colocalization of [18/19F]-4 PET, fluorescence, scintillated biodistribution, and PSMA expression are observed. © 2018 American Chemical Society. |
| Journal Title: | Journal of Medicinal Chemistry |
| Volume: | 61 |
| Issue: | 9 |
| ISSN: | 0022-2623 |
| Publisher: | American Chemical Society |
| Date Published: | 2018-05-10 |
| Start Page: | 4256 |
| End Page: | 4262 |
| Language: | English |
| DOI: | 10.1021/acs.jmedchem.8b00240 |
| PROVIDER: | scopus |
| PUBMED: | 29676909 |
| PMCID: | PMC6263152 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 June 2018 -- Source: Scopus |
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