Repeatability of [(68)Ga]DKFZ11-PSMA PET scans for detecting prostate-specific membrane antigen-positive prostate cancer Journal Article

   


Authors: Osborne, J. R.; Kalidindi, T. M.; Punzalan, B. J.; Gangangari, K.; Spratt, D. E.; Weber, W. A.; Larson, S. M.; Pillarsetty, N. V. K.
Article Title: Repeatability of [(68)Ga]DKFZ11-PSMA PET scans for detecting prostate-specific membrane antigen-positive prostate cancer
Abstract: Purpose: We studied the effect of varying specific activity of [68Ga]DKFZ-PSMA11 ([68Ga]DP11) on repeated imaging of prostate-specific membrane antigen-positive (PSMA+) xenograft tumors. Procedures: Athymic nude mice bearing PC3-PIP (PSMA+) and PC3 (PSMA−) bilateral flank tumors were assessed to study intra- and inter-day repeatability of [68Ga]DP11 imaging in mice administered [68Ga]DP11 or [67Ga]DP11 (as a dilution tracer) using imaging and biodistribution studies. Results: Region of interest (ROI) analysis of the [68Ga]DP11 imaging study indicated that the uptake was constant on the same day or consecutive days. Prior imaging with [68Ga]DP11 did not significantly influence the subsequent uptake of [68Ga]DP11. Uptake of [68Ga]DP11 (60 min) and [67Ga]DP11 (24 h) in PC3-PIP tumors was 12.37 ± 4.19 %ID/g and 12.49 ± 6.88 %ID/g, respectively; [68Ga]DP11 was 13.83 ± 3.77 and 17.76 ± 1.84 on same-day and 15.98 ± 5.82 %ID/g on second-day imaging. Conclusions: This study demonstrates that [68Ga]DP11, in a given PSMA+ lesion, is constant under several same-day or serial-day imaging conditions. © 2017, World Molecular Imaging Society.
Keywords: unclassified drug; nonhuman; positron emission tomography; cancer diagnosis; sensitivity and specificity; mouse; mice; animal tissue; animal experiment; animal model; cohort analysis; tumor xenograft; prostate cancer; prostate specific membrane antigen; drug uptake; radiopharmaceutical agent; solution and solubility; specific activity; repeatability; psma; priority journal; article; gallium-68; dp11 ga 68
Journal Title: Molecular Imaging and Biology
Volume: 19
Issue: 6
ISSN: 1536-1632
Publisher: Springer  
Date Published: 2017-12-01
Start Page: 944
End Page: 951
Language: English
DOI: 10.1007/s11307-017-1091-9
PROVIDER: scopus
PMCID: PMC5664162
PUBMED: 28534214
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019848659&doi=10.1007%2fs11307-017-1091-9&partnerID=40&md5=77fc0f2a18fa8c516a969af67968ebde
Notes: Article -- Erratum issued, see DOI 10.1007/s11307-017-1104-8 -- Export Date: 1 December 2017 -- Source: Scopus
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MSK Authors
  1. Joseph R Osborne
    61 Osborne
  2. Nagavarakishore Pillarsetty
    132 Pillarsetty
  3. Steven M Larson
    958 Larson
  4. Blesida Punzalan
    38 Punzalan
  5. Wolfgang Andreas Weber
    173 Weber
  6. Teja Muralidhar Kalidindi
    38 Kalidindi
  7. Kishore Kumar Gangangari
    11 Gangangari
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