| Abstract: |
We report a case of polyostotic Paget's disease of bone that caused an unusual pattern of accumulation of In-111 leukocytes that mimicked, at some sites, uptake of osteomyelitis, which was suspected in this patient, Technetium-99m sulfur colloid scan clarified the nature of In-111-leukocyte accumulation as secondary to expanded active bone marrow uptake in some pagetic bones, Additionally, a spectrum of In-111-leukocyte and Tc-99m-sulfur colloid uptake was noted in the bones involved by the disease that represented uptake by pagetic fool at different pathologic phases of the disease, This case suggests that Paget's disease should be considered as a diagnostic possibility for areas of In-111-leukocyte accumulation, particularly when expanded uptake is seen. When suspected, correlation with bone marrow scan and/or standard radiographs should be obtained, Recognizing that Paget's disease cannot only cause absent but also expanded bone marrow (depending on the disease stage) and consequently abnormal In-111 leukocyte uptake, should help avoid interpretational confusion. |
